((2S,4R)-2-Phenyl-4-trimethylsilanyl-tetrahydro-furan-2-yl)-methanol

Base Information

• Chemical Name: ((2S,4R)-2-Phenyl-4-trimethylsilanyl-tetrahydro-furan-2-yl)-methanol
• CAS No.: 155139-38-1
• Molecular Formula: C₁₄H₂₂O₂Si
• Molecular Weight: 250.413
• Mol file: 155139-38-1.mol

Synonyms:((2S,4R)-2-Phenyl-4-trimethylsilanyl-tetrahydro-furan-2-yl)-methanol

Chemical Property of ((2S,4R)-2-Phenyl-4-trimethylsilanyl-tetrahydro-furan-2-yl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2S,4R)-2-Phenyl-4-trimethylsilanyl-tetrahydro-furan-2-yl)-methanol

There total 2 articles about ((2S,4R)-2-Phenyl-4-trimethylsilanyl-tetrahydro-furan-2-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C38H60O8Si2 (160560-48-5) → ((2S,4R)-2-Phenyl-4-trimethylsilanyl-tetrahydro-furan-2-yl)-methanol (155139-38-1)

Guidance literature:

With lithium borohydride;

DOI:10.1016/S0040-4039(00)74417-0

Reference yield:

1L-4-O-benzoylformyl-3-O-(t-butyldimethylsilyl)-1,2:5,6-di-O-cyclohexylidene-chiro-inositol (134221-96-8) → ((2S,4R)-2-Phenyl-4-trimethylsilanyl-tetrahydro-furan-2-yl)-methanol (155139-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / tin (IV) chloride / CH₂Cl₂ / 0.08 h / Ambient temperature

2: 85 percent / LiBH₄

With lithium borohydride; tin(IV) chloride; In dichloromethane;

DOI:10.1016/S0040-4039(00)74417-0

Reference yield: 46.0%

((2S,4R)-2-Phenyl-4-trimethylsilanyl-tetrahydro-furan-2-yl)-methanol (155139-38-1) → (S)-(2-phenyl-tetrahydrofuran-2-yl)methanol

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 60 ℃; for 14h;

DOI:10.1016/S0040-4039(00)74417-0

upstream raw materials:

C₃₈H₆₀O₈Si₂

1L-4-O-benzoylformyl-3-O-(t-butyldimethylsilyl)-1,2:5,6-di-O-cyclohexylidene-chiro-inositol

Downstream raw materials:

(2S)-2-hydroxy-2-phenyl-4-pentenoic acid