· N-(3-(cyclopropylmethoxy)benzyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide

Base Information

Chemical Name:· N-(3-(cyclopropylmethoxy)benzyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide
CAS No.:1198221-17-8
Molecular Formula:C₁₉H₂₅N₃O₆S
Molecular Weight:423.49
Hs Code.:

Synonyms:· N-(3-(cyclopropylmethoxy)benzyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide

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Chemical Property of · N-(3-(cyclopropylmethoxy)benzyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide

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Technology Process of · N-(3-(cyclopropylmethoxy)benzyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide

There total 7 articles about · N-(3-(cyclopropylmethoxy)benzyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1198223-97-0
N-(3-(cyclopropylmethoxy)benzyl)-3-(methoxymethoxy)propane-1-sulfonamide

: 10457-14-4
O,O'-bis-(trimethylsilyl)uracil

: 1198221-17-8
· N-(3-(cyclopropylmethoxy)benzyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide

Guidance literature:: N-(3-(cyclopropylmethoxy)benzyl)-3-(methoxymethoxy)propane-1-sulfonamide; With boron trichloride; In dichloromethane; at 0 - 20 ℃; for 1.5h;

O,O'-bis-(trimethylsilyl)uracil; With iodine; In 1,2-dichloro-ethane; at 95 ℃; for 3.5h;

With water; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 873-62-1
m-cyanophenol

: 1198221-17-8
· N-(3-(cyclopropylmethoxy)benzyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 4 h / 90 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 45 °C

2.2: 0 °C

3.1: triethylamine / dichloromethane / 12 h / 0 - 20 °C

4.1: sodium iodide; sodium acetate / N,N-dimethyl-formamide / 8 h / 80 °C

5.1: hydrogenchloride / methanol / 1 h / 80 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

7.1: boron trichloride / dichloromethane / 1.5 h / 0 - 20 °C

7.2: 3.5 h / 95 °C

7.3: 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium acetate; boron trichloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1198223-99-2
C₁₄H₂₁NO₄S

: 1198221-17-8
· N-(3-(cyclopropylmethoxy)benzyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2.1: boron trichloride / dichloromethane / 1.5 h / 0 - 20 °C

2.2: 3.5 h / 95 °C

2.3: 20 °C

With boron trichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;