5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester

Base Information

Chemical Name:5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester
CAS No.:1333000-86-4
Molecular Formula:C₂₅H₂₀F₃N₅O₃
Molecular Weight:495.461
Hs Code.:

5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester

Synonyms:5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester

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Chemical Property of 5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester

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Technology Process of 5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester

There total 3 articles about 5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1333000-85-3
5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1333000-86-4
5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester

Guidance literature:: 5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester; (meta-(trifluoromethyl)phenyl)boronic acid; With pyridine; copper diacetate; In dichloromethane; at 20 ℃; for 16h;

With triethylamine; In dichloromethane; at 20 - 50 ℃; for 240h;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1333000-86-4
5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 2 h / Cooling with ice

2.2: 0.17 h

3.1: pyridine; copper diacetate / dichloromethane / 16 h / 20 °C

3.2: 240 h / 20 - 50 °C

With pyridine; copper diacetate; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1118-84-9
allyl acetoacetate

: 1333000-86-4
5-(4-cyanophenyl)-2,7-dimethyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 2 h / Cooling with ice

2.2: 0.17 h

3.1: pyridine; copper diacetate / dichloromethane / 16 h / 20 °C

3.2: 240 h / 20 - 50 °C

With pyridine; copper diacetate; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;