(S)-3-(4'-chlorophenyl)-3-hydroxypropanenitrile

Base Information

Chemical Name:(S)-3-(4'-chlorophenyl)-3-hydroxypropanenitrile
CAS No.:324574-51-8
Molecular Formula:C₉H₈ClNO
Molecular Weight:181.622
Hs Code.:

Synonyms:(S)-3-(4'-chlorophenyl)-3-hydroxypropanenitrile

Suppliers and Price of (S)-3-(4'-chlorophenyl)-3-hydroxypropanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-3-(4'-chlorophenyl)-3-hydroxypropanenitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-3-(4'-chlorophenyl)-3-hydroxypropanenitrile

There total 9 articles about (S)-3-(4'-chlorophenyl)-3-hydroxypropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 4640-66-8
p-chlorobenzoylacetonitrile

: 324574-51-8
(S)-3-(4'-chlorophenyl)-3-hydroxypropanenitrile

Guidance literature:: With (p-cymene)ruthenium(II) chloride; triethylamine; N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide; In dichloromethane; at 35 ℃; for 1h;

p-chlorobenzoylacetonitrile; With tetra-(n-butyl)ammonium iodide; In water; sodium formate; at 40 ℃; for 4h; optical yield given as %ee; Ultrasonic irradiation;
DOI:10.1016/j.catcom.2009.12.002

Reference yield: 47.0%

: 108-05-4,9003-20-7
vinyl acetate

: 84466-38-6
(RS)-3-(4-chlorophenyl)-3-hydroxypropionitrile

: 324574-51-8
(S)-3-(4'-chlorophenyl)-3-hydroxypropanenitrile

: (R)-3-acetyloxy-3-(4-chlorophenyl)propanenitrile

Guidance literature:: With Pseudomonas cepacia lipase on modified ceramic particles; In di-isopropyl ether; at 27 ℃; for 7.5h;
DOI:10.1016/S0957-4166(02)00537-2

Reference yield:

: 90712-54-2
5-(4-chlorophenyl)-4,5-dihydroisoxazole

: (R)-3-hydroxy-3-(4’-chlorophenyl)-propanenitrile

: C₉H₈ClNO

: 324574-51-8
(S)-3-(4'-chlorophenyl)-3-hydroxypropanenitrile

Guidance literature:: With sodium dithionite; aldoxime dehydratase from Pseudomonas chlororaphis B₂₃; In aq. phosphate buffer; at 30 ℃; for 3h; pH=7.0; Reagent/catalyst; enantioselective reaction; Resolution of racemate; Enzymatic reaction;
DOI:10.1039/d0gc01445a