(S)-benzyl 3-(o-tolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:(S)-benzyl 3-(o-tolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1383448-89-2
Molecular Formula:C₂₅H₂₄N₂O₃
Molecular Weight:400.477
Hs Code.:

Synonyms:(S)-benzyl 3-(o-tolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of (S)-benzyl 3-(o-tolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of (S)-benzyl 3-(o-tolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 2 articles about (S)-benzyl 3-(o-tolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₁NO₆

: 95-53-4
o-toluidine

: 1383448-89-2
(S)-benzyl 3-(o-tolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.tetasy.2012.04.010

Reference yield:

: 79261-58-8
(S)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester

: 1383448-89-2
(S)-benzyl 3-(o-tolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: dichloromethane / 18 h / 20 °C

With triethylamine; In dichloromethane;
DOI:10.1016/j.tetasy.2012.04.010

Reference yield: 90.0%

: 1383448-89-2
(S)-benzyl 3-(o-tolylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1383448-92-7
(S)-N-O-tolyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; under 760.051 Torr;
DOI:10.1016/j.tetasy.2012.04.010