{3-[{3-[(4-amino-butyl)-(2-nitro-benzenesulfonyl)-amino]-1-methyl-propyl}-(2-nitro-benzenesulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{3-[{3-[(4-amino-butyl)-(2-nitro-benzenesulfonyl)-amino]-1-methyl-propyl}-(2-nitro-benzenesulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester
CAS No.:618902-53-7
Molecular Formula:C₂₈H₄₂N₆O₁₀S₂
Molecular Weight:686.808
Hs Code.:

{3-[{3-[(4-amino-butyl)-(2-nitro-benzenesulfonyl)-amino]-1-methyl-propyl}-(2-nitro-benzenesulfonyl)-amino]-propyl}-carbamic acid <i>tert</i>-butyl ester

Synonyms:{3-[{3-[(4-amino-butyl)-(2-nitro-benzenesulfonyl)-amino]-1-methyl-propyl}-(2-nitro-benzenesulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester

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Chemical Property of {3-[{3-[(4-amino-butyl)-(2-nitro-benzenesulfonyl)-amino]-1-methyl-propyl}-(2-nitro-benzenesulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester

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Technology Process of {3-[{3-[(4-amino-butyl)-(2-nitro-benzenesulfonyl)-amino]-1-methyl-propyl}-(2-nitro-benzenesulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester

There total 8 articles about {3-[{3-[(4-amino-butyl)-(2-nitro-benzenesulfonyl)-amino]-1-methyl-propyl}-(2-nitro-benzenesulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 618902-52-6
{4-[{3-[(3-tert-butoxycarbonylamino-propyl)-(2-nitro-benzenesulfonyl)-amino]-butyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

: 618902-53-7
{3-[{3-[(4-amino-butyl)-(2-nitro-benzenesulfonyl)-amino]-1-methyl-propyl}-(2-nitro-benzenesulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 50 ℃; for 4h;
DOI:10.1002/ejoc.200300186

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 618902-53-7
{3-[{3-[(4-amino-butyl)-(2-nitro-benzenesulfonyl)-amino]-1-methyl-propyl}-(2-nitro-benzenesulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / Et₃N / CH₂Cl₂ / 4 h

2: 89 percent / DIPEA / tetrahydrofuran / 2 h / 50 °C

3: 70 percent / tributylphosphane; 1,1'-(azodicarbonyl)dipiperidide / tetrahydrofuran / 24 h / 20 °C

4: 68 percent / trimethylphosphane; 1,1'-(azodicarbonyl)dipiperidide / tetrahydrofuran / 40 h / 20 °C

5: 62 percent / Bu₄NF*3H₂O / tetrahydrofuran / 4 h / 50 °C

With 1,1'-carbonyldipiperidine; tributylphosphine; tetrabutyl ammonium fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; trimethylphosphane; In tetrahydrofuran; dichloromethane; 3: Fukuyama-Mitsunobu coupling / 4: Fukuyama-Mitsunobu coupling;
DOI:10.1002/ejoc.200300186

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 618902-53-7
{3-[{3-[(4-amino-butyl)-(2-nitro-benzenesulfonyl)-amino]-1-methyl-propyl}-(2-nitro-benzenesulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / methanol / 22 h

2: 68 percent / trimethylphosphane; 1,1'-(azodicarbonyl)dipiperidide / tetrahydrofuran / 40 h / 20 °C

3: 62 percent / Bu₄NF*3H₂O / tetrahydrofuran / 4 h / 50 °C

With 1,1'-carbonyldipiperidine; tetrabutyl ammonium fluoride; trimethylphosphane; In tetrahydrofuran; methanol; 2: Fukuyama-Mitsunobu coupling;
DOI:10.1002/ejoc.200300186