ethyl N-methoxymethyl-N-(N’-methoxymethyl-N'-p-nitrophenylcarbamoyl)-L-phenylalaninate

Base Information

Chemical Name:ethyl N-methoxymethyl-N-(N’-methoxymethyl-N'-p-nitrophenylcarbamoyl)-L-phenylalaninate
CAS No.:1451376-08-1
Molecular Formula:C₂₂H₂₇N₃O₇
Molecular Weight:445.472
Hs Code.:

Synonyms:ethyl N-methoxymethyl-N-(N’-methoxymethyl-N'-p-nitrophenylcarbamoyl)-L-phenylalaninate

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Chemical Property of ethyl N-methoxymethyl-N-(N’-methoxymethyl-N'-p-nitrophenylcarbamoyl)-L-phenylalaninate

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Technology Process of ethyl N-methoxymethyl-N-(N’-methoxymethyl-N'-p-nitrophenylcarbamoyl)-L-phenylalaninate

There total 4 articles about ethyl N-methoxymethyl-N-(N’-methoxymethyl-N'-p-nitrophenylcarbamoyl)-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1451376-39-8
C₂₀H₂₃N₃O₆

: 107-30-2
chloromethyl methyl ether

: 1451376-08-1
ethyl N-methoxymethyl-N-(N’-methoxymethyl-N'-p-nitrophenylcarbamoyl)-L-phenylalaninate

Guidance literature:: C₂₀H₂₃N₃O₆; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.25h;

chloromethyl methyl ether; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ja406653n

Reference yield:

: 1451376-35-4
C₁₈H₁₉N₃O₅

: 1451376-08-1
ethyl N-methoxymethyl-N-(N’-methoxymethyl-N'-p-nitrophenylcarbamoyl)-L-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane / 0 - 20 °C

1.2: 0.5 h / 0 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C

2.2: -78 °C

With chloro-trimethyl-silane; potassium hexamethylsilazane; In tetrahydrofuran;
DOI:10.1021/ja406653n

Reference yield:

: 3182-93-2
(L)-phenylalanine ethyl ester hydrochloride

: 1451376-08-1
ethyl N-methoxymethyl-N-(N’-methoxymethyl-N'-p-nitrophenylcarbamoyl)-L-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

2.1: chloro-trimethyl-silane / 0 - 20 °C

2.2: 0.5 h / 0 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C

3.2: -78 °C

With chloro-trimethyl-silane; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja406653n