6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide

Base Information

Chemical Name:6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide
CAS No.:1201660-57-2
Molecular Formula:C₂₈H₃₁Cl₄N₃O₄S
Molecular Weight:647.45
Hs Code.:

Synonyms:6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide

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Chemical Property of 6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide

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Technology Process of 6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide

There total 5 articles about 6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 1201663-49-1
3,5-dichloro-N-(3-chloro-5-((isobutylamino)methyl)benzyl)-2-hydroxy-N-isobutylbenzenesulfonamide

: 1201660-57-2
6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide

Guidance literature:: 6-Chloro-3-pyridinecarboxylic acid; 3,5-dichloro-N-(3-chloro-5-((isobutylamino)methyl)benzyl)-2-hydroxy-N-isobutylbenzenesulfonamide; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

With sodium hydroxide; In tetrahydrofuran; water; for 2h;

Reference yield:

: 1201663-46-8
[3-chloro-5-(isobutylamino-methyl)-benzyl]-isobutyl-amine

: 1201660-57-2
6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 2 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

4.2: 2 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1201663-45-7
5-chloro-N₁,N₃-diisobutylisophthalamide

: 1201660-57-2
6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: diborane / tetrahydrofuran / 38 h / 20 - 60 °C / Inert atmosphere

1.2: 2 h

1.3: pH 9

2.1: acetonitrile / 2 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

5.2: 2 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; diborane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;