6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide

Base Information

• Chemical Name: 6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide
• CAS No.: 1201660-57-2
• Molecular Formula: C₂₈H₃₁Cl₄N₃O₄S
• Molecular Weight: 647.45
• Mol file: 1201660-57-2.mol

Synonyms:6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide

Chemical Property of 6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide

There total 5 articles about 6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) + 3,5-dichloro-N-(3-chloro-5-((isobutylamino)methyl)benzyl)-2-hydroxy-N-isobutylbenzenesulfonamide (1201663-49-1) → 6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide (1201660-57-2)

Guidance literature:

6-Chloro-3-pyridinecarboxylic acid; 3,5-dichloro-N-(3-chloro-5-((isobutylamino)methyl)benzyl)-2-hydroxy-N-isobutylbenzenesulfonamide; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

With sodium hydroxide; In tetrahydrofuran; water; for 2h;

Reference yield:

[3-chloro-5-(isobutylamino-methyl)-benzyl]-isobutyl-amine (1201663-46-8) → 6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide (1201660-57-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetonitrile / 2 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

4.2: 2 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

5-chloro-N1,N3-diisobutylisophthalamide (1201663-45-7) → 6-chloro-N-(3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl)-N-isobutylnicotinamide (1201660-57-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: diborane / tetrahydrofuran / 38 h / 20 - 60 °C / Inert atmosphere

1.2: 2 h

1.3: pH 9

2.1: acetonitrile / 2 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

5.2: 2 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; diborane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

6-Chloro-3-pyridinecarboxylic acid

3,5-dichloro-N-(3-chloro-5-((isobutylamino)methyl)benzyl)-2-hydroxy-N-isobutylbenzenesulfonamide

[3-chloro-5-(isobutylamino-methyl)-benzyl]-isobutyl-amine

5-chloro-N₁,N₃-diisobutylisophthalamide

Refernces