(S)-4-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)-3-methylbutanoate

Base Information

• Chemical Name: (S)-4-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)-3-methylbutanoate
• CAS No.: 1121627-43-7
• Molecular Formula: C₂₆H₂₄Cl₂N₂O₅
• Molecular Weight: 515.393
• Mol file: 1121627-43-7.mol

Synonyms:(S)-4-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)-3-methylbutanoate

Chemical Property of (S)-4-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)-3-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)-3-methylbutanoate

There total 3 articles about (S)-4-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) + 4',5-dichlorosalicylanilide (1147-98-4) → (S)-4-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)-3-methylbutanoate (1121627-43-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at -10 ℃; for 4h;

DOI:10.1016/j.bmcl.2008.11.080

Reference yield:

5-chloro-2-hydroxybenzoic acid (321-14-2) → (S)-4-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)-3-methylbutanoate (1121627-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus trichloride / chlorobenzene / Microwave irradiation

2: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 4 h / -10 °C

With dicyclohexyl-carbodiimide; phosphorus trichloride; In N,N-dimethyl-formamide; chlorobenzene;

DOI:10.1016/j.bmcl.2008.11.080

Reference yield:

4-chloro-aniline (106-47-8) → (S)-4-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)-3-methylbutanoate (1121627-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus trichloride / chlorobenzene / Microwave irradiation

2: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 4 h / -10 °C

With dicyclohexyl-carbodiimide; phosphorus trichloride; In N,N-dimethyl-formamide; chlorobenzene;

DOI:10.1016/j.bmcl.2008.11.080

upstream raw materials:

5-chloro-2-hydroxybenzoic acid

(S)-N-(benzyloxycarbonyl)valine

4',5-dichlorosalicylanilide

4-chloro-aniline

Downstream raw materials:

C₁₈H₁₈Cl₂N₂O₃

BrH*C₁₈H₁₈Cl₂N₂O₃