1-(1,3-benzothiazol-2-yl)-3-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde

Base Information

• Chemical Name: 1-(1,3-benzothiazol-2-yl)-3-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde
• CAS No.: 1609564-61-5
• Molecular Formula: C₁₈H₁₃N₃OS
• Molecular Weight: 319.387
• Mol file: 1609564-61-5.mol

Synonyms:1-(1,3-benzothiazol-2-yl)-3-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde

Chemical Property of 1-(1,3-benzothiazol-2-yl)-3-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1,3-benzothiazol-2-yl)-3-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde

There total 4 articles about 1-(1,3-benzothiazol-2-yl)-3-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-[(Z)-2-[1-(4-methylphenyl)ethylidene]hydrazin-1-yl]-1,3-benzothiazole + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-(1,3-benzothiazol-2-yl)-3-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde (1609564-61-5)

Guidance literature:

With trichlorophosphate; at 55 - 60 ℃; for 5h; Cooling;

DOI:10.2174/1386207321666180213092911

Reference yield: 70.0%

(E)-2-(2-(1-(p-tolyl)ethylidene)hydrazinyl)benzo[d]thiazole (1609564-58-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-(1,3-benzothiazol-2-yl)-3-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde (1609564-61-5)

Guidance literature:

With trichlorophosphate; In chloroform-d1; at 60 ℃; for 18h; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.bmc.2014.04.014

Reference yield:

para-methylacetophenone (122-00-9) → 1-(1,3-benzothiazol-2-yl)-3-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde (1609564-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / water / 18 h / 20 °C / Inert atmosphere

2: trichlorophosphate / chloroform-d1 / 18 h / 60 °C / Inert atmosphere; Cooling with ice

With acetic acid; trichlorophosphate; In chloroform-d1; water;

DOI:10.1016/j.bmc.2014.04.014

upstream raw materials:

1,3-benzothiazol-2-ylhydrazine

(E)-2-(2-(1-(p-tolyl)ethylidene)hydrazinyl)benzo[d]thiazole

N,N-dimethyl-formamide

para-methylacetophenone

Downstream raw materials:

1-(benzo[d]thiazol-2-yl)-3-(p-tolyl)-1H-pyrazole-4-carboxylic acid

1-(benzo[d]thiazol-2-yl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide