N-hydroxy-5-((4-methoxybenzyloxy)methyl)-2,2-diinethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide

Base Information

Chemical Name:N-hydroxy-5-((4-methoxybenzyloxy)methyl)-2,2-diinethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide
CAS No.:1198620-47-1
Molecular Formula:C₁₉H₂₂N₂O₆
Molecular Weight:374.393
Hs Code.:

Synonyms:N-hydroxy-5-((4-methoxybenzyloxy)methyl)-2,2-diinethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide

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Chemical Property of N-hydroxy-5-((4-methoxybenzyloxy)methyl)-2,2-diinethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide

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Technology Process of N-hydroxy-5-((4-methoxybenzyloxy)methyl)-2,2-diinethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide

There total 5 articles about N-hydroxy-5-((4-methoxybenzyloxy)methyl)-2,2-diinethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1198621-16-7
N-(benzyloxy)-5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide

: 1198620-47-1
N-hydroxy-5-((4-methoxybenzyloxy)methyl)-2,2-diinethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 1h;

Reference yield:

: 1198621-14-5
methyl 5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate

: 1198620-47-1
N-hydroxy-5-((4-methoxybenzyloxy)methyl)-2,2-diinethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 23 °C

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 0.25 h / 23 °C

2.2: 17 h / 23 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h

With lithium hydroxide monohydrate; water; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; acetonitrile;

Reference yield:

: 280762-58-5
5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carbaldehyde

: 1198620-47-1
N-hydroxy-5-((4-methoxybenzyloxy)methyl)-2,2-diinethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; potassium hydroxide / 0 - 23 °C

1.2: 4 h / 20 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 18 h / 23 °C

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 0.25 h / 23 °C

3.2: 17 h / 23 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h

With lithium hydroxide monohydrate; water; hydrogen; iodine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; potassium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; acetonitrile;