Technology Process of 2-(imidazo[1,5-a]pyridin-8-ylmethoxy)-5-methoxybenzaldehyde
There total 8 articles about 2-(imidazo[1,5-a]pyridin-8-ylmethoxy)-5-methoxybenzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 80 - 90 ℃;
for 5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: N,N-Dimethylcarbamoyl chloride / dichloromethane / 48 h / 20 °C / Inert atmosphere
3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; water / 12 h / 20 °C / Inert atmosphere
4.1: acetic anhydride / 3 h / 50 - 60 °C / Inert atmosphere
4.2: 8 h / 20 °C / Inert atmosphere
4.3: Inert atmosphere
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux; Inert atmosphere
5.2: 0.5 h / 20 °C / Inert atmosphere
6.1: thionyl chloride / chloroform / 8 h / 20 °C / Inert atmosphere
7.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 - 90 °C / Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; palladium 10% on activated carbon; hydrogen; acetic anhydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N,N-Dimethylcarbamoyl chloride / dichloromethane / 48 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; water / 12 h / 20 °C / Inert atmosphere
3.1: acetic anhydride / 3 h / 50 - 60 °C / Inert atmosphere
3.2: 8 h / 20 °C / Inert atmosphere
3.3: Inert atmosphere
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux; Inert atmosphere
4.2: 0.5 h / 20 °C / Inert atmosphere
5.1: thionyl chloride / chloroform / 8 h / 20 °C / Inert atmosphere
6.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 - 90 °C / Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; palladium 10% on activated carbon; hydrogen; acetic anhydride; potassium carbonate; N,N-Dimethylcarbamoyl chloride;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
