2-(4-(hex-5-ynyloxy)phenyl)-N-methoxy-N-methyl-3H-benzoimidazole-5-carboxamide

Base Information

Chemical Name:2-(4-(hex-5-ynyloxy)phenyl)-N-methoxy-N-methyl-3H-benzoimidazole-5-carboxamide
CAS No.:1268487-53-1
Molecular Formula:C₂₂H₂₃N₃O₃
Molecular Weight:377.443
Hs Code.:

Synonyms:2-(4-(hex-5-ynyloxy)phenyl)-N-methoxy-N-methyl-3H-benzoimidazole-5-carboxamide

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Chemical Property of 2-(4-(hex-5-ynyloxy)phenyl)-N-methoxy-N-methyl-3H-benzoimidazole-5-carboxamide

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Technology Process of 2-(4-(hex-5-ynyloxy)phenyl)-N-methoxy-N-methyl-3H-benzoimidazole-5-carboxamide

There total 5 articles about 2-(4-(hex-5-ynyloxy)phenyl)-N-methoxy-N-methyl-3H-benzoimidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 231634-78-9
4-(hex-5-yn-1-yloxy)benzaldehyde

: 391903-19-8
N-methoxy N-methyl 3,4-dinitrobenzoic acid amide

: 1268487-53-1
2-(4-(hex-5-ynyloxy)phenyl)-N-methoxy-N-methyl-3H-benzoimidazole-5-carboxamide

Guidance literature:: N-methoxy N-methyl 3,4-dinitrobenzoic acid amide; With palladium 10% on activated carbon; hydrogen; In ethanol; for 5h; under 760.051 Torr;

4-(hex-5-yn-1-yloxy)benzaldehyde; With sodium metabisulfite; In ethanol; water; for 8h; Reflux;

Reference yield: 74.0%

: 231634-78-9
4-(hex-5-yn-1-yloxy)benzaldehyde

: 660432-02-0
N-methoxy N-methyl 3,4-diaminobenzoic acid amide

: 1268487-53-1
2-(4-(hex-5-ynyloxy)phenyl)-N-methoxy-N-methyl-3H-benzoimidazole-5-carboxamide

Guidance literature:: With sodium metabisulfite; In water; for 20h; Reflux;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1268487-53-1
2-(4-(hex-5-ynyloxy)phenyl)-N-methoxy-N-methyl-3H-benzoimidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane; 1,4-dioxane / 7 h / 0 - 20 °C / Inert atmosphere

2: sodium metabisulfite / water / 8 h / Reflux

With sodium metabisulfite; di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; dichloromethane; water; 1: |Mitsunobu Displacement;
DOI:10.1039/c4md00140k