Dihydroxycarbazepine

Base Information

Chemical Name:Dihydroxycarbazepine
CAS No.:35079-97-1
Molecular Formula:C15H14 N2 O3
Molecular Weight:270.288
Hs Code.:2933990090
DSSTox Substance ID:DTXSID30891504
Nikkaji Number:J372.992C
Wikidata:Q27106416
Metabolomics Workbench ID:67955
Mol file:35079-97-1.mol

Synonyms:10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide;10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide, (10S,trans)-isomer;10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide, (cis)-isomer;10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide, (trans)-isomer;10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide, (trans-(+-))-isomer;10,11-dihydro-10,11-dihydroxycarbamazepine;10,11-dihydro-10,11-transdihydroxycarbamazepine;10,11-dihydroxy-10,11-dihydrocarbamazepine;10,11-dihydroxycarbamazepine;carbamazepine-10,11-diol;carbamazepine-10,11-transdiol;carbazepine 10,11-diol;CBZ-diol;CBZD;CGP 10,000;CGP-10,000

Suppliers and Price of Dihydroxycarbazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of Dihydroxycarbazepine

Chemical Property:

Vapor Pressure:1.43E-08mmHg at 25°C
Melting Point:208-210?C
Boiling Point:441.4°Cat760mmHg
PKA:12.94±0.40(Predicted)
Flash Point:220.8°C
PSA：87.78000
Density:1.443g/cm³
LogP:2.56260
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
XLogP3:0.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:270.10044231
Heavy Atom Count:20
Complexity:348

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(C(C3=CC=CC=C3N2C(=O)N)O)O
Uses A major metabolite of Carbamazepine.

Technology Process of Dihydroxycarbazepine

There total 4 articles about Dihydroxycarbazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 298-46-4
carbamazepin

: 36507-30-9
carbamazepine 10,11-epoxide

: 35079-97-1,58955-93-4
10,11 dihydro 10,11 dihydroxy 5h dibenz[b,f]azepine 5 carboxamide

Guidance literature:: With [bis(acetoxy)iodo]benzene; Mn^IIIBr₈T₄CMPPCl; In dichloromethane; at 25 ℃; for 1h;
DOI:10.1016/j.apcata.2011.09.001

Reference yield:

: 36507-30-9
carbamazepine 10,11-epoxide

: 35079-97-1,58955-93-4
10,11 dihydro 10,11 dihydroxy 5h dibenz[b,f]azepine 5 carboxamide

Guidance literature:: With [bis(acetoxy)iodo]benzene; In dichloromethane; at 25 ℃;
DOI:10.1016/j.apcata.2011.09.001

Reference yield:

: 298-46-4
carbamazepin

: 35079-97-1,58955-93-4
10,11 dihydro 10,11 dihydroxy 5h dibenz[b,f]azepine 5 carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butylhydroperoxide; Mn^IIIBr₈T₄CMPPCl / dichloromethane / 1 h / 25 °C

2: [bis(acetoxy)iodo]benzene / dichloromethane / 25 °C

With tert.-butylhydroperoxide; [bis(acetoxy)iodo]benzene; Mn^IIIBr₈T₄CMPPCl; In dichloromethane;
DOI:10.1016/j.apcata.2011.09.001