<1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

Base Information

Chemical Name:<1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester
CAS No.:132294-26-9
Molecular Formula:C₂₇H₂₆O₇S
Molecular Weight:494.565
Hs Code.:

Synonyms:<1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

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Chemical Property of <1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

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Technology Process of <1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

There total 8 articles about <1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 132294-25-8
<1R-(1α,2β,3β)>-3-hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester

: 98-59-9
p-toluenesulfonyl chloride

: 132294-26-9
<1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

Guidance literature:: at 57 ℃; for 8h;
DOI:10.1021/jm00108a026

Reference yield: 72.0%

: 126261-73-2,126373-88-4,127759-90-4,127759-93-7,132294-17-8,132294-25-8
C₂₀H₂₀O₅

: 98-59-9
p-toluenesulfonyl chloride

: 126261-74-3,127759-91-5,132294-18-9,132294-26-9
(1α,2β,3β)-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol, dibenzoate ester

Guidance literature:: In pyridine; at 60 ℃; for 16h;
DOI:10.1016/S0040-4039(01)88992-9

Reference yield:

: 132178-71-3
trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid

: 132294-26-9
<1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

Guidance literature:: Multi-step reaction with 6 steps

1: DCC / CH₂Cl₂ / Ambient temperature

2: imidazole / dimethylformamide / 1.5 h / 5 °C

3: N₂O₄, NaOAc / CCl₄ / 0.25 h / 5 °C

4: 95 percent / 0.5 N H₂SO₄ / acetonitrile / 17 h / Ambient temperature

5: 70 percent / LS-Selectride / tetrahydrofuran / 0.17 h / -78 °C

6: 84 percent / 8 h / 57 °C

With 1H-imidazole; sulfuric acid; sodium acetate; dinitrogen tetraoxide; lithium tri-sec-butyl(hydrido)borate; dicyclohexyl-carbodiimide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00108a026