but-3-yn-1-yl 5-[(4-methylbenzene)sulfonyl]-5H-[1,2,4]triazino[5,6-b]indole-3-carboxylate

Base Information

Chemical Name:but-3-yn-1-yl 5-[(4-methylbenzene)sulfonyl]-5H-[1,2,4]triazino[5,6-b]indole-3-carboxylate
CAS No.:1394236-99-7
Molecular Formula:C₂₁H₁₆N₄O₄S
Molecular Weight:420.448
Hs Code.:

Synonyms:but-3-yn-1-yl 5-[(4-methylbenzene)sulfonyl]-5H-[1,2,4]triazino[5,6-b]indole-3-carboxylate

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Chemical Property of but-3-yn-1-yl 5-[(4-methylbenzene)sulfonyl]-5H-[1,2,4]triazino[5,6-b]indole-3-carboxylate

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Technology Process of but-3-yn-1-yl 5-[(4-methylbenzene)sulfonyl]-5H-[1,2,4]triazino[5,6-b]indole-3-carboxylate

There total 4 articles about but-3-yn-1-yl 5-[(4-methylbenzene)sulfonyl]-5H-[1,2,4]triazino[5,6-b]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1394237-82-1
ethyl 5-[(4-methylbenzene)sulfonyl]-5H-[1,2,4]triazino[5,6-b]indole-3-carboxylate

: 927-74-2
3-Butyn-1-ol

: 1394236-99-7
but-3-yn-1-yl 5-[(4-methylbenzene)sulfonyl]-5H-[1,2,4]triazino[5,6-b]indole-3-carboxylate

Guidance literature:: With Otera’s Catalyst; In toluene; at 105 ℃; for 12h; Inert atmosphere;
DOI:10.3762/bjoc.8.93

Reference yield:

: 1394237-93-4
C₁₂H₁₀N₄O₂

: 1394236-99-7
but-3-yn-1-yl 5-[(4-methylbenzene)sulfonyl]-5H-[1,2,4]triazino[5,6-b]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 7 h / 20 °C / Inert atmosphere

2.1: Otera’s Catalyst / toluene / 12 h / 105 °C / Inert atmosphere

With Otera’s Catalyst; triethylamine; In tetrahydrofuran; toluene;
DOI:10.3762/bjoc.8.93

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1394236-99-7
but-3-yn-1-yl 5-[(4-methylbenzene)sulfonyl]-5H-[1,2,4]triazino[5,6-b]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 7 h / 20 °C / Inert atmosphere

2.1: Otera’s Catalyst / toluene / 12 h / 105 °C / Inert atmosphere

With Otera’s Catalyst; triethylamine; In tetrahydrofuran; toluene;
DOI:10.3762/bjoc.8.93