N-{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-2-cyclopentyl-acetamide

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Chemical Name:N-{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-2-cyclopentyl-acetamide
CAS No.:126541-17-1
Molecular Formula:C₃₀H₃₁ClN₄O₅S
Molecular Weight:595.119
Hs Code.:

Synonyms:N-{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-2-cyclopentyl-acetamide

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Chemical Property of N-{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-2-cyclopentyl-acetamide

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Technology Process of N-{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-2-cyclopentyl-acetamide

There total 2 articles about N-{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-2-cyclopentyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 6961-82-6
2-chlorobenzenesulfonamide

: 126502-25-8
4-[5-(2-Cyclopentyl-acetylamino)-1-methyl-1H-indazol-3-ylmethyl]-3-methoxy-benzoic acid

: 126541-17-1
N-{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-2-cyclopentyl-acetamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 18h;
DOI:10.1021/jm00168a037

Reference yield:

: 4-[5-(2-Cyclopentyl-acetylamino)-1-methyl-1H-indazol-3-ylmethyl]-3-methoxy-benzoic acid methyl ester

: 126541-17-1
N-{3-[4-(2-Chloro-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indazol-5-yl}-2-cyclopentyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / LiOH monohydrate / tetrahydrofuran; methanol; H₂O / 20 h

2: 74 percent / 4-(dimethylamino)pyridine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h

With dmap; lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00168a037