5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Base Information

Chemical Name:5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine
CAS No.:1429869-70-4
Molecular Formula:C₁₆H₁₈FN₃O₂
Molecular Weight:303.336
Hs Code.:

Synonyms:5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Chemical Property of 5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Technology Process of 5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

There total 7 articles about 5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429869-75-9
(5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester

: 1429869-70-4
5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: (5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 - 50 ℃; for 4h;

With trifluoroacetic acid; In 1,4-dioxane; at 50 ℃; for 7h;

Reference yield:

: 1266784-13-7
rac-5-(5-bromo-2-fluorophenyl)-5-methylmorpholin-3-one

: 1429869-70-4
5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: Lawessons reagent / tetrahydrofuran / 16 h / 20 °C / Reflux

2.1: tert.-butylhydroperoxide; ammonium hydroxide; ammonia / water; methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4.1: sodium L-ascorbate; copper(l) iodide; sodium azide; cis-N,N'-dimethyl-1,2-diaminocyclohexane / water; ethanol / 1 h / 70 °C / Inert atmosphere

5.1: hydrogen; palladium 10% on activated carbon / ethanol; ethyl acetate / 4.5 h / 20 °C / 75.01 Torr

6.1: sodium acetate / methanol / 0.25 h / 100 °C / Microwave irradiation; Inert atmosphere

6.2: 1 h / 0 - 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 - 50 °C

7.2: 7 h / 50 °C

With Lawessons reagent; hydrogenchloride; tert.-butylhydroperoxide; ammonium hydroxide; copper(l) iodide; sodium azide; palladium 10% on activated carbon; ammonia; hydrogen; sodium acetate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 1429869-71-5
rac-5-(5-bromo-2-fluorophenyl)-5-methylmorpholine-3-thione

: 1429869-70-4
5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: tert.-butylhydroperoxide; ammonium hydroxide; ammonia / water; methanol / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3.1: sodium L-ascorbate; copper(l) iodide; sodium azide; cis-N,N'-dimethyl-1,2-diaminocyclohexane / water; ethanol / 1 h / 70 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / ethanol; ethyl acetate / 4.5 h / 20 °C / 75.01 Torr

5.1: sodium acetate / methanol / 0.25 h / 100 °C / Microwave irradiation; Inert atmosphere

5.2: 1 h / 0 - 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 - 50 °C

6.2: 7 h / 50 °C

With hydrogenchloride; tert.-butylhydroperoxide; ammonium hydroxide; copper(l) iodide; sodium azide; palladium 10% on activated carbon; ammonia; hydrogen; sodium acetate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate;