(2S)-N-{4-(3-[2-(2-pyridyl)benzimidazol-1-yl]propyl)oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Chemical Name:(2S)-N-{4-(3-[2-(2-pyridyl)benzimidazol-1-yl]propyl)oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal
CAS No.:1187383-61-4
Molecular Formula:C₃₂H₃₇N₅O₅S₂
Molecular Weight:635.808
Hs Code.:

Synonyms:(2S)-N-{4-(3-[2-(2-pyridyl)benzimidazol-1-yl]propyl)oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Chemical Property of (2S)-N-{4-(3-[2-(2-pyridyl)benzimidazol-1-yl]propyl)oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Technology Process of (2S)-N-{4-(3-[2-(2-pyridyl)benzimidazol-1-yl]propyl)oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

There total 7 articles about (2S)-N-{4-(3-[2-(2-pyridyl)benzimidazol-1-yl]propyl)oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1137-68-4
2-(2'-pyridyl)benzimidazole

: 343308-55-4
(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

: 1187383-61-4
(2S)-N-{4-(3-[2-(2-pyridyl)benzimidazol-1-yl]propyl)oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.2174/1573406411309050004

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 1187383-61-4
(2S)-N-{4-(3-[2-(2-pyridyl)benzimidazol-1-yl]propyl)oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 48 h / Reflux

2: tin(IV) chloride; nitric acid / dichloromethane / 0.08 h / -25 °C

3: lithium hydroxide; methanol / water; tetrahydrofuran / 12 h / 20 °C

4: thionyl chloride; triethylamine / water; N,N-dimethyl-formamide; tetrahydrofuran; benzene / 6 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

With methanol; thionyl chloride; nitric acid; tin(IV) chloride; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.2174/1573406411309050004

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 1187383-61-4
(2S)-N-{4-(3-[2-(2-pyridyl)benzimidazol-1-yl]propyl)oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 2 steps

1: sodium metabisulfite / ethanol; water / 4 h

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

With sodium metabisulfite; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.2174/1573406411309050004