(S)-tert-butyl (1-((2-chloro-4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-((2-chloro-4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
CAS No.:860399-69-5
Molecular Formula:C₂₀H₂₂ClN₃O₅
Molecular Weight:419.865
Hs Code.:

Synonyms:(S)-tert-butyl (1-((2-chloro-4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl (1-((2-chloro-4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

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Technology Process of (S)-tert-butyl (1-((2-chloro-4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

There total 1 articles about (S)-tert-butyl (1-((2-chloro-4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 121-87-9
2-Chloro-4-nitroaniline

: 860399-69-5
(S)-tert-butyl (1-((2-chloro-4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Guidance literature:: With trichlorophosphate; In pyridine; at -15 ℃; for 1.5h;
DOI:10.1021/jm050184y

Reference yield:

: 860399-69-5
(S)-tert-butyl (1-((2-chloro-4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

: L-phenylalanine-2-chloro-4-nitroanilide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 1.5h;
DOI:10.1021/jm050184y

Reference yield:

: 860399-69-5
(S)-tert-butyl (1-((2-chloro-4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

: (2R,5S)-2-Isobutyl-6-methyl-4-oxo-5-propionylamino-heptanoic acid [(S)-1-(2-chloro-4-nitro-phenylcarbamoyl)-2-phenyl-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / dioxane / 1.5 h / 25 °C

2: HOBt; EDCl; (i-Pr)2NEt / CH₂Cl₂ / 20 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm050184y