(R)-1-[(1R,2R)-2-((S)-2-Hydroxy-3-methyl-butylamino)-cyclohexylamino]-3-methyl-butan-2-ol

Base Information

Chemical Name:(R)-1-[(1R,2R)-2-((S)-2-Hydroxy-3-methyl-butylamino)-cyclohexylamino]-3-methyl-butan-2-ol
CAS No.:847340-83-4
Molecular Formula:C₁₆H₃₄N₂O₂
Molecular Weight:286.458
Hs Code.:

Synonyms:(R)-1-[(1R,2R)-2-((S)-2-Hydroxy-3-methyl-butylamino)-cyclohexylamino]-3-methyl-butan-2-ol

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Chemical Property of (R)-1-[(1R,2R)-2-((S)-2-Hydroxy-3-methyl-butylamino)-cyclohexylamino]-3-methyl-butan-2-ol

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Technology Process of (R)-1-[(1R,2R)-2-((S)-2-Hydroxy-3-methyl-butylamino)-cyclohexylamino]-3-methyl-butan-2-ol

There total 4 articles about (R)-1-[(1R,2R)-2-((S)-2-Hydroxy-3-methyl-butylamino)-cyclohexylamino]-3-methyl-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 847340-82-3
(R)-2-Hydroxy-N-[(1R,2R)-2-((S)-2-hydroxy-3-methyl-butyrylamino)-cyclohexyl]-3-methyl-butyramide

: 847340-83-4
(R)-1-[(1R,2R)-2-((S)-2-Hydroxy-3-methyl-butylamino)-cyclohexylamino]-3-methyl-butan-2-ol

Guidance literature:: (R)-2-Hydroxy-N-[(1R,2R)-2-((S)-2-hydroxy-3-methyl-butyrylamino)-cyclohexyl]-3-methyl-butyramide; With boron trifluoride diethyl etherate; In tetrahydrofuran; Heating;

With dimethylsulfide borane complex; In tetrahydrofuran; for 18h; Heating;

With hydrogenchloride; for 1h; Heating;
DOI:10.1016/j.tet.2004.11.030

Reference yield:

: 847340-81-2
(R)-N-((1R,2R)-2-Amino-cyclohexyl)-2-hydroxy-3-methyl-butyramide

: 847340-83-4
(R)-1-[(1R,2R)-2-((S)-2-Hydroxy-3-methyl-butylamino)-cyclohexylamino]-3-methyl-butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole; 1-hydroxybenzotriazole hydrate / tetrahydrofuran / 1.5 h

1.2: 42 percent / tetrahydrofuran / 16 h / 20 °C

2.1: boron trifluoride etherate / tetrahydrofuran / Heating

2.2: borane-dimethyl sulfide complex / tetrahydrofuran / 18 h / Heating

2.3: 40 percent / hydrochloric acid / 1 h / Heating

With boron trifluoride diethyl etherate; 1-hydroxybenzotriazol-hydrate; 1,1'-carbonyldiimidazole; In tetrahydrofuran;
DOI:10.1016/j.tet.2004.11.030

Reference yield:

: 17407-56-6
(R)-2-Hydroxy-3-methylbutyric acid

: 847340-83-4
(R)-1-[(1R,2R)-2-((S)-2-Hydroxy-3-methyl-butylamino)-cyclohexylamino]-3-methyl-butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole; 1-hydroxybenzotriazole / tetrahydrofuran / 1 h

1.2: 4 percent / tetrahydrofuran / 16 h / 20 °C

2.1: 1,1'-carbonyldiimidazole; 1-hydroxybenzotriazole hydrate / tetrahydrofuran / 1.5 h

2.2: 42 percent / tetrahydrofuran / 16 h / 20 °C

3.1: boron trifluoride etherate / tetrahydrofuran / Heating

3.2: borane-dimethyl sulfide complex / tetrahydrofuran / 18 h / Heating

3.3: 40 percent / hydrochloric acid / 1 h / Heating

With boron trifluoride diethyl etherate; benzotriazol-1-ol; 1-hydroxybenzotriazol-hydrate; 1,1'-carbonyldiimidazole; In tetrahydrofuran;
DOI:10.1016/j.tet.2004.11.030