acetic acid 5-benzyloxy-2-(2-formyl-6-methoxy-4-methyl-phenyl)-4-methoxy-naphthalen-1-yl ester

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Chemical Name:acetic acid 5-benzyloxy-2-(2-formyl-6-methoxy-4-methyl-phenyl)-4-methoxy-naphthalen-1-yl ester
CAS No.:742101-70-8
Molecular Formula:C₂₉H₂₆O₆
Molecular Weight:470.522
Hs Code.:

Synonyms:acetic acid 5-benzyloxy-2-(2-formyl-6-methoxy-4-methyl-phenyl)-4-methoxy-naphthalen-1-yl ester

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Chemical Property of acetic acid 5-benzyloxy-2-(2-formyl-6-methoxy-4-methyl-phenyl)-4-methoxy-naphthalen-1-yl ester

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Technology Process of acetic acid 5-benzyloxy-2-(2-formyl-6-methoxy-4-methyl-phenyl)-4-methoxy-naphthalen-1-yl ester

There total 10 articles about acetic acid 5-benzyloxy-2-(2-formyl-6-methoxy-4-methyl-phenyl)-4-methoxy-naphthalen-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 742101-66-2
acetic acid 5-benzyloxy-2-(2-[1,3]dioxan-2-yl-6-methoxy-4-methyl-phenyl)-4-methoxy-naphthalen-1-yl ester

: 742101-70-8
acetic acid 5-benzyloxy-2-(2-formyl-6-methoxy-4-methyl-phenyl)-4-methoxy-naphthalen-1-yl ester

Guidance literature:: With acetic acid; at 25 ℃; for 4h;
DOI:10.1021/ol049261u

Reference yield:

: 175165-88-5
methyl-3-methoxy-5-methyl-2-(trifluoromethanesulfonyloxy)benzoate

: 742101-70-8
acetic acid 5-benzyloxy-2-(2-formyl-6-methoxy-4-methyl-phenyl)-4-methoxy-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 68 percent / (Ph₃P)2PdCl₂; Et₃N / dimethylformamide / 7 h / 90 °C

2.1: 96 percent / K₂CO₃ / methanol / 1 h / 25 °C

3.1: 95 percent / Et₄N⁽¹⁺⁾*(HBr₂)^(1-) / CH₂Cl₂ / 0.5 h / 25 °C

4.1: 90 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / -78 - 0 °C

5.1: 89 percent / MnO₂ / CHCl₃ / 7.5 h / Heating

6.1: 85 percent / TsOH / toluene / 0.75 h / Heating

7.1: t-BuLi / tetrahydrofuran / 0.17 h / -78 °C

7.2: 100 percent / tetrahydrofuran / 0.08 h / -78 °C

8.1: toluene / 8.5 h / 110 °C

9.1: DMAP; pyridine

10.1: 98 percent / aq. AcOH / 4 h / 25 °C

With pyridine; dmap; manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; Et₄N⁽¹⁺⁾*(HBr₂)^(1-); tert.-butyl lithium; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 1.1: Sonogashira reaction;
DOI:10.1021/ol049261u

Reference yield:

: 742101-69-5
2-(1-bromo-vinyl)-3-methoxy-5-methyl-benzaldehyde

: 742101-70-8
acetic acid 5-benzyloxy-2-(2-formyl-6-methoxy-4-methyl-phenyl)-4-methoxy-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / TsOH / toluene / 0.75 h / Heating

2.1: t-BuLi / tetrahydrofuran / 0.17 h / -78 °C

2.2: 100 percent / tetrahydrofuran / 0.08 h / -78 °C

3.1: toluene / 8.5 h / 110 °C

4.1: DMAP; pyridine

5.1: 98 percent / aq. AcOH / 4 h / 25 °C

With pyridine; dmap; tert.-butyl lithium; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; toluene;
DOI:10.1021/ol049261u