2-(3,4-dimethoxyphenoxy)ethyl (S)-1-(benzo[d]thiazol-6-ylsulfonyl)piperidine-2-carboxylate

Base Information

• Chemical Name: 2-(3,4-dimethoxyphenoxy)ethyl (S)-1-(benzo[d]thiazol-6-ylsulfonyl)piperidine-2-carboxylate
• CAS No.: 1373829-78-7
• Molecular Formula: C₂₃H₂₆N₂O₇S₂
• Molecular Weight: 506.601
• Mol file: 1373829-78-7.mol

Synonyms:2-(3,4-dimethoxyphenoxy)ethyl (S)-1-(benzo[d]thiazol-6-ylsulfonyl)piperidine-2-carboxylate

Chemical Property of 2-(3,4-dimethoxyphenoxy)ethyl (S)-1-(benzo[d]thiazol-6-ylsulfonyl)piperidine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-dimethoxyphenoxy)ethyl (S)-1-(benzo[d]thiazol-6-ylsulfonyl)piperidine-2-carboxylate

There total 4 articles about 2-(3,4-dimethoxyphenoxy)ethyl (S)-1-(benzo[d]thiazol-6-ylsulfonyl)piperidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(S)-2-(3,4-dimethoxyphenoxy)ethyl piperidine-2-carboxylate (1373830-22-8) + 1,3-benzothiazole-6-sulfonyl chloride (181124-40-3) → 2-(3,4-dimethoxyphenoxy)ethyl (S)-1-(benzo[d]thiazol-6-ylsulfonyl)piperidine-2-carboxylate (1373829-78-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jm201747c

Reference yield:

(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid (26250-84-0) → 2-(3,4-dimethoxyphenoxy)ethyl (S)-1-(benzo[d]thiazol-6-ylsulfonyl)piperidine-2-carboxylate (1373829-78-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetone;

DOI:10.1021/jm400087k

Reference yield:

4-(2-bromoethoxy)-1,2-dimethoxybenzene (2033-77-4) → 2-(3,4-dimethoxyphenoxy)ethyl (S)-1-(benzo[d]thiazol-6-ylsulfonyl)piperidine-2-carboxylate (1373829-78-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetone;

DOI:10.1021/jm400087k

upstream raw materials:

(S)-2-(3,4-dimethoxyphenoxy)ethyl piperidine-2-carboxylate

1,3-benzothiazole-6-sulfonyl chloride

(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

4-(2-bromoethoxy)-1,2-dimethoxybenzene