Chemical Property of Aviptadil
Chemical Property:
- Appearance/Colour:powder
- PSA：1478.99000
- Density:1.47±0.1 g/cm3(Predicted)
- LogP:4.02270
- Storage Temp.:−20°C
- Solubility.:1% acetic acid: soluble 0.1%, clear, colorless
- XLogP3:-15.9
- Hydrogen Bond Donor Count:51
- Hydrogen Bond Acceptor Count:51
- Rotatable Bond Count:115
- Exact Mass:3325.7434694
- Heavy Atom Count:234
- Complexity:7580
- Purity/Quality:
-
99% *data from raw suppliers
Vasoactive Intestinal Peptide *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)C(CO)NC(=O)C(CC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)O)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CC4=CN=CN4)N
- Isomeric SMILES:CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CN=CN4)N
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Biological functions
VIP is extensively distributed in central and peripheral
tissues, where it acts as a neurotransmitter and neuromodulator.8 The main activity of VIP is vasodilatation. VIP
induces the dilation of vessels, which results in increased
blood flow, decreased peripheral vascular resistance, and
hypotension. While VIP has a suppressive effect on the
intestinal smooth muscle, it exerts relaxant effects on
the lower esophageal sphincter, the sphincter of Oddi,
the anal sphincter, and the bronchial smooth muscle. In
the small intestine, VIP facilitates the secretion of electrolytes and aqueous liquid. In the stomach, it inhibits gastric secretion. In the pancreas, VIP facilitates the external
secretion of bicarbonic acid and aqueous liquid from pancreatic epithelial cells, and facilitates enzyme secretion
from acinar cells. VIP promotes the secretion of both insulin and glucagon in a glucose-dependent manner. VIP is
broadly distributed in the central nervous system, especially in the hypothalamus and pituitary anterior lobe,
and is associated with the regulation of pituitary hormones. VIP is produced by lymphoid tissue and exerts
a wide spectrum of immunological functions, controlling
the homeostasis of the immune system through different
receptors expressed in various immunocompetent cells.?VIP acts as a growth factor. It functions as a proliferative
factor in normal tissue cells as well as in cancer cells. VIP
might inhibit apoptosis by stimulating the expression of
the apoptosis-inhibiting gene Bcl2 or by inhibiting the
activity of caspase 3.
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Uses
Pulmonary hypertension;Erectile dysfunction Vasoactive Intestinal Peptide human, porcine, rat has been used as an immunogen to analyze the immunohistochemical reactions. It has also been used in cell migration assay.
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Clinical Use
28-peptide that is structurally related to
secretin and glucagon. It has a diverse
biological actions. It has orphan drug
status for the treatment of acute
esophageal food impaction. Several clinical trials have been reported regarding the
use of VIP or its analog for asthma and sarcoidosis. In an
open clinical Phase II study, patients with histologically
proven sarcoidosis and active disease were treated with
nebulized VIP. VIP inhalation was safe and well tolerated, and significantly reduced the production of tumor
necrosis factor-α by cells isolated from the bronchoalveolar lavage fluids of these patients.
