C₆₀H₈₁NO₁₅Si₂

Base Information

• Chemical Name: C₆₀H₈₁NO₁₅Si₂
• CAS No.: 168479-08-1
• Molecular Formula: C₆₀H₈₁NO₁₅Si₂
• Molecular Weight: 1112.47
• Mol file: 168479-08-1.mol

Synonyms:C₆₀H₈₁NO₁₅Si₂

Chemical Property of C₆₀H₈₁NO₁₅Si₂

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₆₀H₈₁NO₁₅Si₂

There total 1 articles about C₆₀H₈₁NO₁₅Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

7-(triethylsilyl)baccatin III (115437-21-3) + (3R,4S)-2-Oxo-4-phenyl-3-triethylsilanyloxy-azetidine-1-carboxylic acid benzyl ester → C60H81NO15Si2 (168479-08-1)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0960-894X(00)00242-0

Reference yield: 94.0%

C60H81NO15Si2 (168479-08-1) → 7,2'-di(O-triethylsilyl)-3'-N-debenzoylpaclitaxel (168479-09-2)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethyl acetate; under 2585.74 Torr;

DOI:10.1016/S0960-894X(00)00242-0

Reference yield:

C60H81NO15Si2 (168479-08-1) → C45H55NO14S

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / H₂ / Pd(OH)2/C / ethyl acetate / 2585.74 Torr

2: 97 percent / EtPr₂N; DMAP / CH₂Cl₂ / 0 °C

3: tetrahydrofuran / 1.5 h / 20 °C

4: 48 percent aq. HF; pyridine / acetonitrile / 12 h / 5 °C

With pyridine; dmap; dipropylethylamine; hydrogen fluoride; hydrogen; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile; 1: Catalytic hydrogenation / 2: Condensation / 3: Substitution / 4: Desilylation;

DOI:10.1016/S0960-894X(00)00242-0

upstream raw materials:

7-(triethylsilyl)baccatin III

Downstream raw materials:

7,2'-di(O-triethylsilyl)-3'-N-debenzoylpaclitaxel

C₅₉H₇₈N₂O₁₇Si₂