5-chloro-N-[4-(methylamino)butanoyl]-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

Base Information

Chemical Name:5-chloro-N-[4-(methylamino)butanoyl]-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride
CAS No.:1101243-59-7
Molecular Formula:C₂₄H₂₆ClFN₄O₆S*ClH
Molecular Weight:589.472
Hs Code.:

5-chloro-N-[4-(methylamino)butanoyl]-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

Synonyms:5-chloro-N-[4-(methylamino)butanoyl]-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

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Chemical Property of 5-chloro-N-[4-(methylamino)butanoyl]-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

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Technology Process of 5-chloro-N-[4-(methylamino)butanoyl]-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

There total 13 articles about 5-chloro-N-[4-(methylamino)butanoyl]-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1101244-15-8
C₃₂H₃₂ClFN₄O₈S

: 1101243-59-7
5-chloro-N-[4-(methylamino)butanoyl]-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

Guidance literature:: C₃₂H₃₂ClFN₄O₈S; With trifluoroacetic acid; at 20 ℃; for 72h;

With hydrogenchloride; In water; pH=3;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1101243-59-7
5-chloro-N-[4-(methylamino)butanoyl]-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium carbonate / dichloromethane; water / 144 h / Reflux

2.1: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / Inert atmosphere; Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 750.08 Torr

4.1: magnesium(II) perchlorate / acetonitrile / 15 h / 20 °C

5.1: dmap / propyl cyanide / 72 h / 70 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 0.25 h / 20 °C

7.1: trifluoroacetic acid / 72 h / 20 °C

7.2: pH 3

With dmap; potassium phosphate; copper(l) iodide; magnesium(II) perchlorate; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium carbonate; trifluoroacetic acid; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In 1,4-dioxane; propyl cyanide; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1093628-67-1
N,N-Dibenzyl-2-fluoro-4-iodoaniline

: 1101243-59-7
5-chloro-N-[4-(methylamino)butanoyl]-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / Inert atmosphere; Reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 750.08 Torr

3.1: magnesium(II) perchlorate / acetonitrile / 15 h / 20 °C

4.1: dmap / propyl cyanide / 72 h / 70 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 0.25 h / 20 °C

6.1: trifluoroacetic acid / 72 h / 20 °C

6.2: pH 3

With dmap; potassium phosphate; copper(l) iodide; magnesium(II) perchlorate; hydrogen; sodium hydride; trifluoroacetic acid; N,N`-dimethylethylenediamine; palladium 10% on activated carbon; In 1,4-dioxane; propyl cyanide; ethanol; N,N-dimethyl-formamide; acetonitrile;