2-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide

Base Information

• Chemical Name: 2-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide
• CAS No.: 356587-85-4
• Molecular Formula: C₁₇H₁₄F₃N₃O₂S
• Molecular Weight: 381.378
• Mol file: 356587-85-4.mol

Synonyms:2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)-N-(3-(trifluoromethyl)phenyl)acetamide

Chemical Property of 2-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide

Chemical Property:

Purity/Quality:

2-[(5-METHOXY-1H-BENZIMIDAZOL-2-YL)SULFANYL]-N-[3-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide

There total 3 articles about 2-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N-chloroacetyl-3-(trifluoromethyl)aniline (351-38-2) + 2-Mercapto-5-methoxybenzimidazole (37052-78-1) → 2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)-N-(3-(trifluoromethyl)phenyl)acetamide (356587-85-4)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 4h;

DOI:10.1007/s00044-013-0732-z

Reference yield:

3-trifluoromethylaniline (98-16-8) → 2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)-N-(3-(trifluoromethyl)phenyl)acetamide (356587-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 0 - 20 °C

2.1: potassium carbonate / acetone / 4 h / 20 °C

With potassium carbonate; triethylamine; In N,N-dimethyl-formamide; acetone;

DOI:10.1007/s00044-013-0732-z

Reference yield:

4-methoxy-1,2-phenylenediamine (102-51-2) → 2-(5-methoxy-1H-benzo[d]imidazol-2-ylthio)-N-(3-(trifluoromethyl)phenyl)acetamide (356587-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; hydrogenchloride / ethanol

2: potassium carbonate / acetone / 4 h / 20 °C

With hydrogenchloride; potassium carbonate; potassium hydroxide; In ethanol; acetone;

DOI:10.1007/s00044-013-0732-z

upstream raw materials:

N-chloroacetyl-3-(trifluoromethyl)aniline

2-Mercapto-5-methoxybenzimidazole

3-trifluoromethylaniline

4-methoxy-1,2-phenylenediamine