(+)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester

Base Information

• Chemical Name: (+)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester
• CAS No.: 858927-51-2
• Molecular Formula: C₂₄H₂₁NO₃
• Molecular Weight: 371.436
• Mol file: 858927-51-2.mol

Synonyms:(+)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester

Chemical Property of (+)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (+)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester

There total 1 articles about (+)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenoxy-1-trimethylsilyloxyethene (111061-31-5) + (E)-2-methoxy-N-(3-phenyl-2-propynylidene)benzenamine → (-)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester + (+)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester (858927-51-2)

Guidance literature:

With isopropyl alcohol; chiral isoleucine-based phosphine ligand; silver(I) acetate; In tetrahydrofuran; at -60 ℃; for 16h; Title compound not separated from byproducts;

DOI:10.1021/ol050910r

Reference yield: 73.0%

(+)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester (858927-51-2) + 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate (3496-11-5) → (R)-3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-5-phenyl-pent-4-ynoic acid phenyl ester

Guidance literature:

(+)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester; 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate; With [bis(acetoxy)iodo]benzene; acetic acid; In methanol;

With hydrogenchloride; In methanol;

With sodium carbonate; In methanol; dichloromethane; water;

DOI:10.1021/ol050910r

Reference yield:

(+)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester (858927-51-2) + di-tert-butyl dicarbonate (24424-99-5) → (+)-3-tert-butoxycarbonylamino-5-phenyl-pent-4-ynoic acid phenyl ester

Guidance literature:

(+)-3-(2-methoxy-phenylamino)-5-phenyl-pent-4-ynoic acid phenyl ester; With [bis(acetoxy)iodo]benzene; acetic acid; In methanol; at 22 ℃; for 1h;

With hydrogenchloride; In methanol; for 0.5h;

di-tert-butyl dicarbonate; With sodium carbonate; In methanol; dichloromethane; water; at 22 ℃; for 12h;

DOI:10.1021/ol050910r

upstream raw materials:

1-phenoxy-1-trimethylsilyloxyethene