(2R,3S)-[(((7-chloroquinolin-4-yl)aminoethyl)-1H-1,2,3-triazol-4-yl)methyl]-3-benzamido-2-hydroxy-3-phenylpropanamide

Base Information

Chemical Name:(2R,3S)-[(((7-chloroquinolin-4-yl)aminoethyl)-1H-1,2,3-triazol-4-yl)methyl]-3-benzamido-2-hydroxy-3-phenylpropanamide
CAS No.:1435474-95-5
Molecular Formula:C₃₀H₂₈ClN₇O₃
Molecular Weight:570.05
Hs Code.:

Synonyms:(2R,3S)-[(((7-chloroquinolin-4-yl)aminoethyl)-1H-1,2,3-triazol-4-yl)methyl]-3-benzamido-2-hydroxy-3-phenylpropanamide

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Chemical Property of (2R,3S)-[(((7-chloroquinolin-4-yl)aminoethyl)-1H-1,2,3-triazol-4-yl)methyl]-3-benzamido-2-hydroxy-3-phenylpropanamide

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Technology Process of (2R,3S)-[(((7-chloroquinolin-4-yl)aminoethyl)-1H-1,2,3-triazol-4-yl)methyl]-3-benzamido-2-hydroxy-3-phenylpropanamide

There total 5 articles about (2R,3S)-[(((7-chloroquinolin-4-yl)aminoethyl)-1H-1,2,3-triazol-4-yl)methyl]-3-benzamido-2-hydroxy-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1145669-30-2
(2-azidoethyl)-(7-chloro-quinolin-4-yl)amine

: 1435474-94-4
(2R,3S)-N-benzoylphenylisoserine aminopropyne

: 1435474-95-5
(2R,3S)-[(((7-chloroquinolin-4-yl)aminoethyl)-1H-1,2,3-triazol-4-yl)methyl]-3-benzamido-2-hydroxy-3-phenylpropanamide

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; at 25 ℃; for 12h;
DOI:10.1021/ml400164t

Reference yield:

: 199444-65-0
2-[(7-chloroquinolin-4-yl)amino]chloroethane

: 1435474-95-5
(2R,3S)-[(((7-chloroquinolin-4-yl)aminoethyl)-1H-1,2,3-triazol-4-yl)methyl]-3-benzamido-2-hydroxy-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / 100 °C / Inert atmosphere

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water / 12 h / 25 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; 2: |Huisgen Cycloaddition;
DOI:10.1021/ml400164t

Reference yield:

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 1435474-95-5
(2R,3S)-[(((7-chloroquinolin-4-yl)aminoethyl)-1H-1,2,3-triazol-4-yl)methyl]-3-benzamido-2-hydroxy-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 7 h / 80 - 130 °C

2: thionyl chloride; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: sodium azide / 100 °C / Inert atmosphere

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water / 12 h / 25 °C

With thionyl chloride; sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; N,N-dimethyl-formamide; In dichloromethane; water; 4: |Huisgen Cycloaddition;
DOI:10.1021/ml400164t