benzyl 2-((S)-3-((S)-3-((S)-3-(tert-butoxy)-2-((S)-sec-butyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidin-1-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)acetate

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Chemical Name:benzyl 2-((S)-3-((S)-3-((S)-3-(tert-butoxy)-2-((S)-sec-butyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidin-1-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)acetate
CAS No.:1316848-26-6
Molecular Formula:C₂₉H₃₉N₃O₅
Molecular Weight:509.646
Hs Code.:

Synonyms:benzyl 2-((S)-3-((S)-3-((S)-3-(tert-butoxy)-2-((S)-sec-butyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidin-1-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)acetate

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Chemical Property of benzyl 2-((S)-3-((S)-3-((S)-3-(tert-butoxy)-2-((S)-sec-butyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidin-1-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)acetate

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Technology Process of benzyl 2-((S)-3-((S)-3-((S)-3-(tert-butoxy)-2-((S)-sec-butyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidin-1-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)acetate

There total 8 articles about benzyl 2-((S)-3-((S)-3-((S)-3-(tert-butoxy)-2-((S)-sec-butyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidin-1-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1316848-20-0
(S)-benzyl 2-(3,5-dioxopyrrolidin-2-yl)acetate

: 1316848-16-4
(S)-4-(tert-butoxy)-5-((S)-sec-butyl)-1-((S)-pyrrolidin-3-yl)-1H-pyrrol-2(5H)-one

: 1316848-26-6
benzyl 2-((S)-3-((S)-3-((S)-3-(tert-butoxy)-2-((S)-sec-butyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidin-1-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)acetate

Guidance literature:: With trimethyl orthoformate; In isopropyl alcohol; at 25 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ja2033734

Reference yield:

: (S)-benzyl 3-(((2S,3S)-1-(tert-butoxy)-3-methyl-1-oxopentan-2-yl)amino)pyrrolidine-1-carboxylate

: 1316848-26-6
benzyl 2-((S)-3-((S)-3-((S)-3-(tert-butoxy)-2-((S)-sec-butyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidin-1-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / diethyl ether / 0.17 h / 0 °C / Inert atmosphere

2: 1,4-dioxane / 24 h / 100 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 25 °C / 760.05 Torr / Inert atmosphere

4: trimethyl orthoformate / isopropyl alcohol / 5 h / 25 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; trimethyl orthoformate; In 1,4-dioxane; methanol; diethyl ether; isopropyl alcohol;
DOI:10.1021/ja2033734

Reference yield:

: C₂₂H₃₄N₂O₄*ClH

: 1316848-26-6
benzyl 2-((S)-3-((S)-3-((S)-3-(tert-butoxy)-2-((S)-sec-butyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidin-1-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-dioxane / 24 h / 100 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 25 °C / 760.05 Torr / Inert atmosphere

3: trimethyl orthoformate / isopropyl alcohol / 5 h / 25 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; trimethyl orthoformate; In 1,4-dioxane; methanol; isopropyl alcohol;
DOI:10.1021/ja2033734