2-Phenyl-3,4,5,6,7,8-hexahydro-2H-cycloheptafuran-3,3-dicarbonitril

Base Information

• Chemical Name: 2-Phenyl-3,4,5,6,7,8-hexahydro-2H-cycloheptafuran-3,3-dicarbonitril
• CAS No.: 73921-08-1
• Molecular Formula: C₁₇H₁₆N₂O
• Molecular Weight: 264.327
• Mol file: 73921-08-1.mol

Synonyms:2-Phenyl-3,4,5,6,7,8-hexahydro-2H-cycloheptafuran-3,3-dicarbonitril

Chemical Property of 2-Phenyl-3,4,5,6,7,8-hexahydro-2H-cycloheptafuran-3,3-dicarbonitril

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Phenyl-3,4,5,6,7,8-hexahydro-2H-cycloheptafuran-3,3-dicarbonitril

There total 3 articles about 2-Phenyl-3,4,5,6,7,8-hexahydro-2H-cycloheptafuran-3,3-dicarbonitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-Dicyanmethylen-2(E)-phenyl-1-oxaspiro<2,6>nonan (73920-96-4) → 2-Phenyl-3,4,5,6,7,8-hexahydro-2H-cycloheptafuran-3,3-dicarbonitril (73921-08-1)

Guidance literature:

In benzene; at 325 ℃; for 0.00416667h;

Reference yield: 50.0%

4-Dicyanmethylen-2(E)-phenyl-1-oxaspiro<2,6>nonan (73920-96-4) + dimethylfumarate (624-49-7) → 2-Phenyl-3,4,5,6,7,8-hexahydro-2H-cycloheptafuran-3,3-dicarbonitril (73921-08-1) + (2S,3R,4R)-6-Dicyanomethylene-2-phenyl-1-oxa-spiro[4.6]undecane-3,4-dicarboxylic acid dimethyl ester + (2R,3R,4R)-6-Dicyanomethylene-2-phenyl-1-oxa-spiro[4.6]undecane-3,4-dicarboxylic acid dimethyl ester

Guidance literature:

at 160 ℃; for 2.2h; Yields of byproduct given;

Reference yield:

(2S,3R)-2-Phenyl-1-oxa-spiro[2.6]nonan-4-one (73920-95-3,106379-12-8) → 2-Phenyl-3,4,5,6,7,8-hexahydro-2H-cycloheptafuran-3,3-dicarbonitril (73921-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / piperidine / CH₂Cl₂ / 4 h / Ambient temperature

2: 80 percent / benzene / 0 h / 325 °C

With piperidine; In dichloromethane; benzene;

upstream raw materials:

4-Dicyanmethylen-2(E)-phenyl-1-oxaspiro<2,6>nonan

dimethylfumarate

(2S,3R)-2-Phenyl-1-oxa-spiro[2.6]nonan-4-one