(2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenoxy)-2-hydroxy-2-methylpropionamide

Base Information

Chemical Name:(2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenoxy)-2-hydroxy-2-methylpropionamide
CAS No.:541497-95-4
Molecular Formula:C₁₈H₁₄F₄N₂O₃
Molecular Weight:382.314
Hs Code.:

Synonyms:(2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenoxy)-2-hydroxy-2-methylpropionamide

Suppliers and Price of (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenoxy)-2-hydroxy-2-methylpropionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenoxy)-2-hydroxy-2-methylpropionamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Technology Process of (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenoxy)-2-hydroxy-2-methylpropionamide

There total 5 articles about (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenoxy)-2-hydroxy-2-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

: 371-41-5
4-Fluorophenol

: 206193-17-1
(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

: 541497-95-4
(2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenoxy)-2-hydroxy-2-methylpropionamide

Guidance literature:: (2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide; With potassium carbonate; In acetone; for 1h; Reflux;

4-Fluorophenol; With potassium carbonate; In isopropyl alcohol; for 2h; Reflux;

Reference yield: 76.9%

: 371-41-5
4-Fluorophenol

: bromoamide ((2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

: 541497-95-4
(2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenoxy)-2-hydroxy-2-methylpropionamide

Guidance literature:: With potassium carbonate; In acetone; butanone;

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 541497-95-4
(2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenoxy)-2-hydroxy-2-methylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: SOCl₂ / tetrahydrofuran / 2 h / -5 - 0 °C

1.2: 76 percent / Et₃N / tetrahydrofuran / -5 - 0 °C / Heating

2.1: K₂CO₃ / acetone / 2 h / Heating

3.1: 3.0 g / K₂CO₃ / butan-2-one / Heating

With thionyl chloride; potassium carbonate; In tetrahydrofuran; acetone; butanone;
DOI:10.1016/j.tetlet.2006.03.154