(4R)-N-benzyloxycarbonyl-4-(2-naphthalenesulfonyloxy)-L-prolyl chloride

Base Information

Chemical Name:(4R)-N-benzyloxycarbonyl-4-(2-naphthalenesulfonyloxy)-L-prolyl chloride
CAS No.:756846-15-8
Molecular Formula:C₂₃H₂₀ClNO₆S
Molecular Weight:473.934
Hs Code.:

Synonyms:(4R)-N-benzyloxycarbonyl-4-(2-naphthalenesulfonyloxy)-L-prolyl chloride

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Chemical Property of (4R)-N-benzyloxycarbonyl-4-(2-naphthalenesulfonyloxy)-L-prolyl chloride

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Technology Process of (4R)-N-benzyloxycarbonyl-4-(2-naphthalenesulfonyloxy)-L-prolyl chloride

There total 3 articles about (4R)-N-benzyloxycarbonyl-4-(2-naphthalenesulfonyloxy)-L-prolyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: (4R)-N-benzyloxycarbonyl-4-(2-naphthalenesulfonyloxy)-L-proline

: 756846-15-8
(4R)-N-benzyloxycarbonyl-4-(2-naphthalenesulfonyloxy)-L-prolyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jo049430o

Reference yield:

: 93-11-8
2-Naphthalenesulfonyl chloride

: 756846-15-8
(4R)-N-benzyloxycarbonyl-4-(2-naphthalenesulfonyloxy)-L-prolyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / NaOH / H₂O / 12 h / 20 °C

2: 86 percent / oxalyl chloride; DMF / CH₂Cl₂ / 12 h / 20 °C

With sodium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; water;
DOI:10.1021/jo049430o

Reference yield:

: 13504-85-3
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 756846-15-8
(4R)-N-benzyloxycarbonyl-4-(2-naphthalenesulfonyloxy)-L-prolyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / NaOH / H₂O / 12 h / 20 °C

2: 86 percent / oxalyl chloride; DMF / CH₂Cl₂ / 12 h / 20 °C

With sodium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; water;
DOI:10.1021/jo049430o