3-[4-[3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-3-oxo-propyl]phenyl]isoxazole-5-carboxylic acid

Base Information

Chemical Name:3-[4-[3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-3-oxo-propyl]phenyl]isoxazole-5-carboxylic acid
CAS No.:1373156-21-8
Molecular Formula:C₂₅H₁₆F₃NO₄
Molecular Weight:451.402
Hs Code.:

Synonyms:3-[4-[3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-3-oxo-propyl]phenyl]isoxazole-5-carboxylic acid

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Chemical Property of 3-[4-[3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-3-oxo-propyl]phenyl]isoxazole-5-carboxylic acid

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Technology Process of 3-[4-[3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-3-oxo-propyl]phenyl]isoxazole-5-carboxylic acid

There total 5 articles about 3-[4-[3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-3-oxo-propyl]phenyl]isoxazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1373156-62-7
C₂₇H₂₀F₃NO₄

: 1373156-21-8
3-[4-[3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-3-oxo-propyl]phenyl]isoxazole-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 12h;
DOI:10.1016/j.bmcl.2012.02.070

Reference yield:

: ethyl 3-(4'-methylphenyl)isoxazole-5-carboxylate

: 1373156-21-8
3-[4-[3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-3-oxo-propyl]phenyl]isoxazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 24 h / 80 °C

2: sodium hydride / N,N-dimethyl-formamide / 3 h / 10 - 15 °C

3: sodium hydroxide / tetrahydrofuran; methanol / 12 h / 25 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmcl.2012.02.070

Reference yield:

: 457948-95-7
2-(4-fluorophenyl)-N-methoxy-N-methylacetamide

: 1373156-21-8
3-[4-[3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-3-oxo-propyl]phenyl]isoxazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 4 h / 0 - 5 °C

2: sodium hydride / N,N-dimethyl-formamide / 3 h / 10 - 15 °C

3: sodium hydroxide / tetrahydrofuran; methanol / 12 h / 25 °C

With sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.02.070