methyl (2E)-3-{(3S,4R,5S)-3-[3-(benzyloxy)propyl]-4-hydroxy-7,8-dimethoxy-2-tosyl-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acrylate

Base Information

Chemical Name:methyl (2E)-3-{(3S,4R,5S)-3-[3-(benzyloxy)propyl]-4-hydroxy-7,8-dimethoxy-2-tosyl-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acrylate
CAS No.:1431116-60-7
Molecular Formula:C₃₃H₃₉NO₈S
Molecular Weight:609.741
Hs Code.:

Synonyms:methyl (2E)-3-{(3S,4R,5S)-3-[3-(benzyloxy)propyl]-4-hydroxy-7,8-dimethoxy-2-tosyl-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acrylate

Suppliers and Price of methyl (2E)-3-{(3S,4R,5S)-3-[3-(benzyloxy)propyl]-4-hydroxy-7,8-dimethoxy-2-tosyl-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (2E)-3-{(3S,4R,5S)-3-[3-(benzyloxy)propyl]-4-hydroxy-7,8-dimethoxy-2-tosyl-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acrylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (2E)-3-{(3S,4R,5S)-3-[3-(benzyloxy)propyl]-4-hydroxy-7,8-dimethoxy-2-tosyl-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acrylate

There total 14 articles about methyl (2E)-3-{(3S,4R,5S)-3-[3-(benzyloxy)propyl]-4-hydroxy-7,8-dimethoxy-2-tosyl-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: methyl (2E,4S,5S,6S)-9-(benzyloxy)-6-[N-(3,4-dimethoxybenzyl)-4-methylphenylsulfonamido]-4,5-epoxy-2-nonenate

: 1431116-60-7
methyl (2E)-3-{(3S,4R,5S)-3-[3-(benzyloxy)propyl]-4-hydroxy-7,8-dimethoxy-2-tosyl-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acrylate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -30 - 20 ℃; for 7h; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2013.03.012

Reference yield:

: C₂₃H₃₁NO₇S

: 1431116-60-7
methyl (2E)-3-{(3S,4R,5S)-3-[3-(benzyloxy)propyl]-4-hydroxy-7,8-dimethoxy-2-tosyl-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acrylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: 1H-imidazole / tetrahydrofuran / 24 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: potassium iodide; sodium hydride / tetrahydrofuran / 6 h / 60 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 °C / Inert atmosphere

6.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

7.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 78 °C / Inert atmosphere

8.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 0.5 h / -30 °C / Inert atmosphere

8.2: 15 h / -30 °C / Inert atmosphere

9.1: Dess-Martin periodane / dichloromethane / 1 h / 0 °C / Inert atmosphere

10.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

11.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 7 h / -30 - 20 °C / Inert atmosphere

With 1H-imidazole; titanium(IV) isopropylate; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; potassium iodide; In tetrahydrofuran; dichloromethane; toluene; 5.1: |Dess-Martin Oxidation / 6.1: |Wittig Olefination / 9.1: |Dess-Martin Oxidation / 10.1: |Wittig Olefination;
DOI:10.1016/j.tet.2013.03.012

Reference yield:

: C₃₉H₄₉NO₇SSi

: 1431116-60-7
methyl (2E)-3-{(3S,4R,5S)-3-[3-(benzyloxy)propyl]-4-hydroxy-7,8-dimethoxy-2-tosyl-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl}acrylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

2.1: potassium iodide; sodium hydride / tetrahydrofuran / 6 h / 60 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

6.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 78 °C / Inert atmosphere

7.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 0.5 h / -30 °C / Inert atmosphere

7.2: 15 h / -30 °C / Inert atmosphere

8.1: Dess-Martin periodane / dichloromethane / 1 h / 0 °C / Inert atmosphere

9.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

10.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 7 h / -30 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; potassium iodide; In tetrahydrofuran; dichloromethane; toluene; 4.1: |Dess-Martin Oxidation / 5.1: |Wittig Olefination / 8.1: |Dess-Martin Oxidation / 9.1: |Wittig Olefination;
DOI:10.1016/j.tet.2013.03.012