2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium chloride

Base Information

• Chemical Name: 2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium chloride
• CAS No.: 1375477-76-1
• Molecular Formula: C₂₇H₃₃N₂S₃*Cl
• Molecular Weight: 517.223

Synonyms:2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium chloride

Chemical Property of 2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium chloride

Chemical Property:

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Technology Process of 2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium chloride

There total 3 articles about 2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium hexafluorophosphate → 2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium chloride (1375477-76-1)

Guidance literature:

With Amberlite-400 (Cl) ion-exchange resin; In methanol; at 20 ℃; for 1h;

DOI:10.1021/jm3004398

Reference yield:

2-tert-butyl-6-[4-(dimethylamino)phenyl]-4H-thiopyran-4-one → 2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium chloride (1375477-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 0.5 h / -78 - 40 °C

2.1: Amberlite-400 (Cl) ion-exchange resin / methanol / 1 h / 20 °C

With lithium diisopropyl amide; In tetrahydrofuran; methanol;

DOI:10.1021/jm3004398

Reference yield:

(piperidin-1-yl)(thiophen-2-yl)methanethione (3335-30-6) → 2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium chloride (1375477-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 0.5 h / -78 - 40 °C

2.1: Amberlite-400 (Cl) ion-exchange resin / methanol / 1 h / 20 °C

With lithium diisopropyl amide; In tetrahydrofuran; methanol;

DOI:10.1021/jm3004398

upstream raw materials:

(piperidin-1-yl)(thiophen-2-yl)methanethione

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