Toluene-4-sulfonic acid 3-(4-oxo-1-phenyl-1,2,3,4-tetrahydro-quinazolin-2-yl)-propyl ester

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Chemical Name:Toluene-4-sulfonic acid 3-(4-oxo-1-phenyl-1,2,3,4-tetrahydro-quinazolin-2-yl)-propyl ester
CAS No.:182679-40-9
Molecular Formula:C₂₄H₂₄N₂O₄S
Molecular Weight:436.532
Hs Code.:

Synonyms:Toluene-4-sulfonic acid 3-(4-oxo-1-phenyl-1,2,3,4-tetrahydro-quinazolin-2-yl)-propyl ester

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Chemical Property of Toluene-4-sulfonic acid 3-(4-oxo-1-phenyl-1,2,3,4-tetrahydro-quinazolin-2-yl)-propyl ester

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Technology Process of Toluene-4-sulfonic acid 3-(4-oxo-1-phenyl-1,2,3,4-tetrahydro-quinazolin-2-yl)-propyl ester

There total 4 articles about Toluene-4-sulfonic acid 3-(4-oxo-1-phenyl-1,2,3,4-tetrahydro-quinazolin-2-yl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 98-59-9
p-toluenesulfonyl chloride

: 182679-38-5
2-(3-Hydroxy-propyl)-1-phenyl-2,3-dihydro-1H-quinazolin-4-one

: 182679-40-9
Toluene-4-sulfonic acid 3-(4-oxo-1-phenyl-1,2,3,4-tetrahydro-quinazolin-2-yl)-propyl ester

Guidance literature:: With pyridine; for 24h;
DOI:10.1002/jhet.5570330427

Reference yield:

: 91-40-7
2-(phenylamino)benzoic acid

: 182679-40-9
Toluene-4-sulfonic acid 3-(4-oxo-1-phenyl-1,2,3,4-tetrahydro-quinazolin-2-yl)-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) thionyl chloride, 2.) aq. ammonia / 1.) toluene, reflux, 1 h, 2.) toluene, 3 h

2: 70 percent / CH₂Cl₂ / 5 h / Ambient temperature

3: 60 percent / LiBH₄ / tetrahydrofuran / 1 h

4: 60 percent / pyridine / 24 h

With pyridine; ammonium hydroxide; lithium borohydride; thionyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/jhet.5570330427

Reference yield:

: 3-(4-Oxo-1-phenyl-1,4-dihydro-quinazolin-2-yl)-propionic acid methyl ester; hydrochloride

: 182679-40-9
Toluene-4-sulfonic acid 3-(4-oxo-1-phenyl-1,2,3,4-tetrahydro-quinazolin-2-yl)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / LiBH₄ / tetrahydrofuran / 1 h

2: 60 percent / pyridine / 24 h

With pyridine; lithium borohydride; In tetrahydrofuran;
DOI:10.1002/jhet.5570330427