p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Base Information

Chemical Name:p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate
CAS No.:105675-87-4
Molecular Formula:C₃₀H₃₂N₄O₁₀S
Molecular Weight:640.671
Hs Code.:

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2-<cis-4-p-nitrobenzyloxycarbonylaminocyclohexylthio>-(5R)-carbapen-2-em-3-carboxylate

Synonyms:p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Suppliers and Price of p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

There total 8 articles about p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74346-66-0
3,3-bis-(1,2,4-triazol-1-yl)-2-thiabicyclo<2.2.2.>oct-5-ene

: 105675-87-4
p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 86.8 percent / hydrogen / 10percent Pd/C / ethyl acetate / 20 h / 2585.7 Torr / Ambient temperature

2: 1N HCl / Heating

3: 62.9 percent / pyridine / CHCl₃ / 72 h / Ambient temperature

4: 1) ClCOOEt, Et₃N, 2) NaN₃ / 1) acetone, H₂O, 2 min, 0 to 5 deg C, 2) acetone, H₂O, 4 min, 0 to 5 deg C

5: 84.2 percent / toluene / 20 h / Heating

6: 1) Hg(OAc)2, 2) H₂S / 1) EtOH, 15 min, RT, 2) CH₂Cl₂, 0, to 5 deg C, 1 h

7: 1) diphenylchlorophosphate, (i-Pr)2NH / 1) CH₃CN, 0 to 5 deg C, 1 h, 2) CH₃CN, RT, 6 d

With pyridine; hydrogenchloride; sodium azide; hydrogen sulfide; mercury(II) diacetate; hydrogen; chloroformic acid ethyl ester; triethylamine; diisopropylamine; chlorophosphoric acid diphenyl ester; palladium on activated charcoal; In chloroform; ethyl acetate; toluene;

Reference yield:

: 105737-63-1
3,3-bis(1,2,4-triazol-1-yl)-2-thiabicyclo<2.2.2>octane

: 105675-87-4
p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1N HCl / Heating

2: 62.9 percent / pyridine / CHCl₃ / 72 h / Ambient temperature

3: 1) ClCOOEt, Et₃N, 2) NaN₃ / 1) acetone, H₂O, 2 min, 0 to 5 deg C, 2) acetone, H₂O, 4 min, 0 to 5 deg C

4: 84.2 percent / toluene / 20 h / Heating

5: 1) Hg(OAc)2, 2) H₂S / 1) EtOH, 15 min, RT, 2) CH₂Cl₂, 0, to 5 deg C, 1 h

6: 1) diphenylchlorophosphate, (i-Pr)2NH / 1) CH₃CN, 0 to 5 deg C, 1 h, 2) CH₃CN, RT, 6 d

With pyridine; hydrogenchloride; sodium azide; hydrogen sulfide; mercury(II) diacetate; chloroformic acid ethyl ester; triethylamine; diisopropylamine; chlorophosphoric acid diphenyl ester; In chloroform; toluene;

Reference yield:

: 619-73-8
4-nitrobenzyl chloride

: 105675-87-4
p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 84.2 percent / toluene / 20 h / Heating

2: 1) Hg(OAc)2, 2) H₂S / 1) EtOH, 15 min, RT, 2) CH₂Cl₂, 0, to 5 deg C, 1 h

3: 1) diphenylchlorophosphate, (i-Pr)2NH / 1) CH₃CN, 0 to 5 deg C, 1 h, 2) CH₃CN, RT, 6 d

With hydrogen sulfide; mercury(II) diacetate; diisopropylamine; chlorophosphoric acid diphenyl ester; In toluene;