2,3,4,7-tetra-O-benzyl-1-O-(p-tolylsulfonyl)-5-epi-(6-⁽²⁾H₂)valiolol

Base Information

• Chemical Name: 2,3,4,7-tetra-O-benzyl-1-O-(p-tolylsulfonyl)-5-epi-(6-⁽²⁾H₂)valiolol
• CAS No.: 620989-88-0
• Molecular Formula: C₄₂H₄₄O₈S
• Molecular Weight: 710.857
• Mol file: 620989-88-0.mol

Synonyms:2,3,4,7-tetra-O-benzyl-1-O-(p-tolylsulfonyl)-5-epi-(6-⁽²⁾H₂)valiolol

Chemical Property of 2,3,4,7-tetra-O-benzyl-1-O-(p-tolylsulfonyl)-5-epi-(6-⁽²⁾H₂)valiolol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,4,7-tetra-O-benzyl-1-O-(p-tolylsulfonyl)-5-epi-(6-⁽²⁾H₂)valiolol

There total 1 articles about 2,3,4,7-tetra-O-benzyl-1-O-(p-tolylsulfonyl)-5-epi-(6-⁽²⁾H₂)valiolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

p-toluenesulfonyl chloride (98-59-9) + 2,3,4,7-tetra-O-benzyl-5-epi-(6-(2)H2)valiolol (620989-86-8) → 2,3,4,7-tetra-O-benzyl-1-O-(p-tolylsulfonyl)-5-epi-(6-(2)H2)valiolol (620989-88-0)

Guidance literature:

With pyridine; dmap; at 20 - 70 ℃; for 20h;

DOI:10.1016/S0008-6215(03)00315-X

Reference yield: 34.0%

2,3,4,7-tetra-O-benzyl-1-O-(p-tolylsulfonyl)-5-epi-(6-(2)H2)valiolol (620989-88-0) → 2,3,4,7-tetra-O-benzyl-1-epi-5-epi-(6-(2)H2)valiolol (620989-89-1)

Guidance literature:

2,3,4,7-tetra-O-benzyl-1-O-(p-tolylsulfonyl)-5-epi-(6-⁽²⁾H₂)valiolol; With potassium acetate; In N,N-dimethyl-formamide; at 60 ℃; for 48h;

With sodium methylate; In methanol; at 20 ℃; for 18h;

DOI:10.1016/S0008-6215(03)00315-X

Reference yield:

2,3,4,7-tetra-O-benzyl-1-O-(p-tolylsulfonyl)-5-epi-(6-(2)H2)valiolol (620989-88-0) → C35H35(2)HO5 + C37H38(2)H2O7

Guidance literature:

With potassium acetate; In N,N-dimethyl-formamide; at 60 ℃; for 48h; Title compound not separated from byproducts;

DOI:10.1016/S0008-6215(03)00315-X

upstream raw materials:

p-toluenesulfonyl chloride

2,3,4,7-tetra-O-benzyl-5-epi-(6-⁽²⁾H₂)valiolol

Downstream raw materials:

2,3,4,7-tetra-O-benzyl-1-epi-5-epi-(6-⁽²⁾H₂)valiolol