N-(2-phenoxy-phenyl)-oxalamic acid

Base Information

• Chemical Name: N-(2-phenoxy-phenyl)-oxalamic acid
• CAS No.: 254751-11-6
• Molecular Formula: C₁₄H₁₁NO₄
• Molecular Weight: 257.246
• Mol file: 254751-11-6.mol

Synonyms:N-(2-phenoxy-phenyl)-oxalamic acid

Chemical Property of N-(2-phenoxy-phenyl)-oxalamic acid

Chemical Property:

Purity/Quality:

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Technology Process of N-(2-phenoxy-phenyl)-oxalamic acid

There total 1 articles about N-(2-phenoxy-phenyl)-oxalamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-phenoxy-phenyl)-oxalamic acid methyl ester → N-(2-phenoxy-phenyl)-oxalamic acid (254751-11-6)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.bmcl.2003.12.106

Reference yield:

(3S)-3-(alaninyl)amino-5-(2′,3′,5′,6′-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester (254750-81-7) + N-(2-phenoxy-phenyl)-oxalamic acid (254751-11-6) → (S)-4-Hydroxy-3-{(S)-2-[(2-phenoxy-phenylaminooxalyl)-amino]-propionylamino}-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid tert-butyl ester

Guidance literature:

(3S)-3-(alaninyl)amino-5-(2′,3′,5′,6′-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.166667h;

N-(2-phenoxy-phenyl)-oxalamic acid; With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jm050307e

Reference yield:

N-(2-phenoxy-phenyl)-oxalamic acid (254751-11-6) + (S)-3-((S)-2-Amino-3-methyl-butyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid tert-butyl ester (254750-78-2) → (S)-4-Hydroxy-3-{(S)-3-methyl-2-[(2-phenoxy-phenylaminooxalyl)-amino]-butyrylamino}-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid tert-butyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2003.12.106