3-Chloro-N-(methoxymethyl)-N-pyridazin-3-yl-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide

Base Information

Chemical Name:3-Chloro-N-(methoxymethyl)-N-pyridazin-3-yl-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide
CAS No.:1354786-90-5
Molecular Formula:C₂₉H₂₁ClF₃N₅O₄S
Molecular Weight:628.031
Hs Code.:

Synonyms:3-Chloro-N-(methoxymethyl)-N-pyridazin-3-yl-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide

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Chemical Property of 3-Chloro-N-(methoxymethyl)-N-pyridazin-3-yl-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide

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Technology Process of 3-Chloro-N-(methoxymethyl)-N-pyridazin-3-yl-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide

There total 4 articles about 3-Chloro-N-(methoxymethyl)-N-pyridazin-3-yl-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354786-61-0
3-chloro-4-fluoro-N-(pyridazin-3-yl)benzenesulfonamide

: 1354786-59-6
3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-ol

: 107-30-2
chloromethyl methyl ether

: 1354786-90-5
3-Chloro-N-(methoxymethyl)-N-pyridazin-3-yl-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide

: 1354786-91-6
3-chloro-N-[(3E)-2-(methoxymethyl)pyridazin-3(2H)-ylidene]-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide

Guidance literature:: 3-chloro-4-fluoro-N-(pyridazin-3-yl)benzenesulfonamide; chloromethyl methyl ether; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;

3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-ol; With potassium carbonate; In dimethyl sulfoxide; at 20 - 100 ℃; for 36h;

Reference yield:

: 1354786-57-4
4-(5-chloro-2-methoxyphenyl)pyridazine

: 1354786-90-5
3-Chloro-N-(methoxymethyl)-N-pyridazin-3-yl-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide

: 1354786-91-6
3-chloro-N-[(3E)-2-(methoxymethyl)pyridazin-3(2H)-ylidene]-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron tribromide / dichloromethane / 18 h / 20 °C

1.2: pH 8 / Cooling with ice

2.1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

3.2: 36 h / 20 - 100 °C

With boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; 2.1: Suzuki Coupling;

Reference yield:

: 1354786-58-5
4-chloro-2-pyridazin-4-ylphenol

: 1354786-90-5
3-Chloro-N-(methoxymethyl)-N-pyridazin-3-yl-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide

: 1354786-91-6
3-chloro-N-[(3E)-2-(methoxymethyl)pyridazin-3(2H)-ylidene]-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

2.2: 36 h / 20 - 100 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; 1.1: Suzuki Coupling;