(RS)(4,4-difluoro-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-phenylpyridin-2-yl)methanone

Base Information

Chemical Name:(RS)(4,4-difluoro-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-phenylpyridin-2-yl)methanone
CAS No.:1454291-01-0
Molecular Formula:C₂₄H₂₁F₅N₄O
Molecular Weight:476.449
Hs Code.:

Synonyms:(RS)(4,4-difluoro-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-phenylpyridin-2-yl)methanone

Suppliers and Price of (RS)(4,4-difluoro-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-phenylpyridin-2-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (RS)(4,4-difluoro-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-phenylpyridin-2-yl)methanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (RS)(4,4-difluoro-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-phenylpyridin-2-yl)methanone

There total 9 articles about (RS)(4,4-difluoro-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-phenylpyridin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454291-33-8
(RS)(3-bromo-6-methylpyridin-2-yl)(4,4-difluoro-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone

: 98-80-6
phenylboronic acid

: 1454291-01-0
(RS)(4,4-difluoro-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-phenylpyridin-2-yl)methanone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; at 120 ℃; for 0.583333h; Sonication; Microwave irradiation;

Reference yield:

: 1259011-99-8
(±) tert-butyl 2-(aminomethyl)-4,4-difluoropiperidine-1-carboxylate

: 1454291-01-0
(RS)(4,4-difluoro-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-phenylpyridin-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 - 120 °C / Inert atmosphere; Microwave irradiation

2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

3.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 0.5 h / 25 °C

3.2: 0.75 h / 80 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 0.58 h / 120 °C / Sonication; Microwave irradiation

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: (±) 1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid

: 1454291-01-0
(RS)(4,4-difluoro-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-phenylpyridin-2-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: borane-THF / tetrahydrofuran / 6.5 h / 0 - 20 °C

2.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0 - 20 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 48 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 - 120 °C / Inert atmosphere; Microwave irradiation

5.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 0.5 h / 25 °C

6.2: 0.75 h / 80 °C

7.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 0.58 h / 120 °C / Sonication; Microwave irradiation

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrazine hydrate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;