(5-phenylamino-1,3,4-thiadiazol-2-yl)thioacetic acid hydrazide

Base Information

• Chemical Name: (5-phenylamino-1,3,4-thiadiazol-2-yl)thioacetic acid hydrazide
• CAS No.: 52494-21-0
• Molecular Formula: C₁₀H₁₁N₅OS₂
• Molecular Weight: 281.362
• Mol file: 52494-21-0.mol

Synonyms:(5-phenylamino-1,3,4-thiadiazol-2-yl)thioacetic acid hydrazide

Chemical Property of (5-phenylamino-1,3,4-thiadiazol-2-yl)thioacetic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-phenylamino-1,3,4-thiadiazol-2-yl)thioacetic acid hydrazide

There total 4 articles about (5-phenylamino-1,3,4-thiadiazol-2-yl)thioacetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-phenylamino-2-mercapto-1,3,4-thiadiazole (10253-83-5) → (5-phenylamino-1,3,4-thiadiazol-2-yl)thioacetic acid hydrazide (52494-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / ethanol / 4 h / Heating

2: hydrazine hydrate / ethanol / 2 h / Heating

With sodium hydroxide; hydrazine hydrate; In ethanol;

Reference yield:

4-Phenyl-3-thiosemicarbazide (5351-69-9) → (5-phenylamino-1,3,4-thiadiazol-2-yl)thioacetic acid hydrazide (52494-21-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 10 h / Reflux

2: potassium carbonate / acetone / 10 h / Reflux

3: hydrazine hydrate / ethanol / 3 h / 20 °C

With potassium carbonate; hydrazine hydrate; sodium hydroxide; In ethanol; acetone;

DOI:10.2174/1570180811666140529004517

Reference yield:

phenyl isothiocyanate (103-72-0) → (5-phenylamino-1,3,4-thiadiazol-2-yl)thioacetic acid hydrazide (52494-21-0)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 5 h / 20 °C

2: sodium hydroxide / ethanol / 10 h / Reflux

3: potassium carbonate / acetone / 10 h / Reflux

4: hydrazine hydrate / ethanol / 3 h / 20 °C

With potassium carbonate; hydrazine hydrate; sodium hydroxide; In ethanol; acetone;

DOI:10.2174/1570180811666140529004517

upstream raw materials:

5-phenylamino-2-mercapto-1,3,4-thiadiazole

4-Phenyl-3-thiosemicarbazide

phenyl isothiocyanate

5-phenylamino-3H-[1,3,4]thiadiazole-2-thione