N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine methyl ester

Base Information

• Chemical Name: N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine methyl ester
• CAS No.: 856865-68-4
• Molecular Formula: C₁₉H₂₉N₃O₈S
• Molecular Weight: 459.521

Synonyms:N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine methyl ester

Chemical Property of N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine methyl ester

There total 3 articles about N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine methyl ester (856865-54-8) + dimethyl sulfate (77-78-1) → N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine methyl ester (856865-68-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

DOI:10.1021/jo050477z

Reference yield:

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride (2389-48-2) → N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine methyl ester (856865-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / triethylamine / CH₂Cl₂

2: 99 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine methyl ester (856865-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / triethylamine / CH₂Cl₂

2: 99 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

upstream raw materials:

N-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine methyl ester

dimethyl sulfate

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

2-Nitrobenzenesulfonyl chloride

Downstream raw materials:

N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-butyloxycarbonyl-L-lysine

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