[3-(2,3-dihydro-1,4-benzodioxin-5-yl)propyl]-(4-methylphenyl)sulphonate

Base Information

• Chemical Name: [3-(2,3-dihydro-1,4-benzodioxin-5-yl)propyl]-(4-methylphenyl)sulphonate
• CAS No.: 261633-74-3
• Molecular Formula: C₁₈H₂₀O₅S
• Molecular Weight: 348.42
• Mol file: 261633-74-3.mol

Synonyms:[3-(2,3-dihydro-1,4-benzodioxin-5-yl)propyl]-(4-methylphenyl)sulphonate

Chemical Property of [3-(2,3-dihydro-1,4-benzodioxin-5-yl)propyl]-(4-methylphenyl)sulphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(2,3-dihydro-1,4-benzodioxin-5-yl)propyl]-(4-methylphenyl)sulphonate

There total 2 articles about [3-(2,3-dihydro-1,4-benzodioxin-5-yl)propyl]-(4-methylphenyl)sulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

p-toluenesulfonyl chloride (98-59-9) + 3-(2,3-dihydro-1,4-benzodioxin-5-yl)propanol (276694-47-4) → [3-(2,3-dihydro-1,4-benzodioxin-5-yl)propyl]-(4-methylphenyl)sulphonate (261633-74-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1211/146080800128735638

Reference yield:

ethyl 3-(2,3-dihydro-1,4-benzodioxin-5-yl)propionate (214895-01-9) → [3-(2,3-dihydro-1,4-benzodioxin-5-yl)propyl]-(4-methylphenyl)sulphonate (261633-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / lithium aluminium hydride / diethyl ether / 1 h / 20 °C

2: 92 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1211/146080800128735638

upstream raw materials:

p-toluenesulfonyl chloride

3-(2,3-dihydro-1,4-benzodioxin-5-yl)propanol

ethyl 3-(2,3-dihydro-1,4-benzodioxin-5-yl)propionate