(+/-)-1-<2-(triphenylmethoxy)ethyl>-3-piperidinecarboxylic acid ethyl ester

Base Information

Chemical Name:(+/-)-1-<2-(triphenylmethoxy)ethyl>-3-piperidinecarboxylic acid ethyl ester
CAS No.:157522-49-1
Molecular Formula:C₂₉H₃₃NO₃
Molecular Weight:443.586
Hs Code.:

Synonyms:(+/-)-1-<2-(triphenylmethoxy)ethyl>-3-piperidinecarboxylic acid ethyl ester

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Chemical Property of (+/-)-1-<2-(triphenylmethoxy)ethyl>-3-piperidinecarboxylic acid ethyl ester

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Technology Process of (+/-)-1-<2-(triphenylmethoxy)ethyl>-3-piperidinecarboxylic acid ethyl ester

There total 4 articles about (+/-)-1-<2-(triphenylmethoxy)ethyl>-3-piperidinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 76-83-5
trityl chloride

: 148319-23-7
(+/-)-1-(2-hydroxyethyl)-3-piperidinecarboxylic acid ethyl ester

: 157522-49-1
(+/-)-1-<2-(triphenylmethoxy)ethyl>-3-piperidinecarboxylic acid ethyl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 25 ℃; for 18h;
DOI:10.1021/jm00041a012

Reference yield:

: 71962-74-8
Ethyl nipecotate

: 157522-49-1
(+/-)-1-<2-(triphenylmethoxy)ethyl>-3-piperidinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / NaI, K₂CO₃ / dioxane / Heating

2: 80 percent / triethylamine, DMAP / tetrahydrofuran / 18 h / 25 °C

With dmap; potassium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00041a012

Reference yield:

: 76-84-6
triphenylmethyl alcohol

: 157522-49-1
(+/-)-1-<2-(triphenylmethoxy)ethyl>-3-piperidinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: conc. H₂SO₄ / toluene / 2 h / 85 - 90 °C

2: K₂CO₃ / acetonitrile / 15 h / Heating

With sulfuric acid; potassium carbonate; In toluene; acetonitrile;
DOI:10.1021/jm00100a032