1-(chloromethyl)-5-nitro-3-(trifluoroacetyl)-1,2-dihydro-3H-benz[e]indole

Base Information

Chemical Name:1-(chloromethyl)-5-nitro-3-(trifluoroacetyl)-1,2-dihydro-3H-benz[e]indole
CAS No.:204915-90-2
Molecular Formula:C₁₅H₁₀ClF₃N₂O₃
Molecular Weight:358.704
Hs Code.:

Synonyms:1-(chloromethyl)-5-nitro-3-(trifluoroacetyl)-1,2-dihydro-3H-benz[e]indole

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Chemical Property of 1-(chloromethyl)-5-nitro-3-(trifluoroacetyl)-1,2-dihydro-3H-benz[e]indole

Chemical Property:

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Technology Process of 1-(chloromethyl)-5-nitro-3-(trifluoroacetyl)-1,2-dihydro-3H-benz[e]indole

There total 1 articles about 1-(chloromethyl)-5-nitro-3-(trifluoroacetyl)-1,2-dihydro-3H-benz[e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 193225-64-8
3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-nitro-1,2-dihydro-3H-benzindole

: 204915-90-2
1-(chloromethyl)-5-nitro-3-(trifluoroacetyl)-1,2-dihydro-3H-benz[e]indole

: 3-[(E)-4-(acetylamino)cinnamoyl]-5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indole

Guidance literature:: With trifluoroacetic anhydride; In pyridine;

Reference yield:

: 204915-90-2
1-(chloromethyl)-5-nitro-3-(trifluoroacetyl)-1,2-dihydro-3H-benz[e]indole

: 3-[(E)-4-(acetylamino)cinnamoyl]-5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indole

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / H₂ / PtO₂ / benzene / 1 h / 50 °C

2: 74 percent / dioxane / 8 h / 70 °C

3: aq. Cs₂CO₃ / 1-methyl-pyrrolidin-2-one / 0.75 h / 20 °C

4: 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide*HCl; DMA; DMA*HCl / 0.5 h / 20 °C

5: 81 percent / HCl(g) / dioxane / 0.17 h / 20 °C

With hydrogenchloride; DMA*HCl; hydrogen; 2,4-dichlorophenoxyacetic acid dimethylamine; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; platinum(IV) oxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; benzene; 1: Reduction / 2: Acylation / 3: Hydrolysis / 4: Condensation / 5: acidolysis;
DOI:10.1021/jm990136b

Reference yield:

: 204915-90-2
1-(chloromethyl)-5-nitro-3-(trifluoroacetyl)-1,2-dihydro-3H-benz[e]indole

: 204915-94-6
{1-chloromethyl-3-[3-(4-methoxy-phenyl)acryloyl]-2,3-dihydro-1H-benzo[e]indol-5-yl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / H₂ / PtO₂ / benzene / 1 h / 50 °C

2: 74 percent / dioxane / 8 h / 70 °C

3: aq. Cs₂CO₃ / 1-methyl-pyrrolidin-2-one / 0.75 h / 20 °C

4: pyridine; DMAP / 0.75 h / 20 °C

With pyridine; dmap; hydrogen; caesium carbonate; platinum(IV) oxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; benzene; 1: Reduction / 2: Acylation / 3: Hydrolysis / 4: Acylation;
DOI:10.1021/jm990136b