2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether

Base Information

• Chemical Name: 2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether
• CAS No.: 223910-48-3
• Molecular Formula: C₅₁H₄₄IN₃O
• Molecular Weight: 841.834
• Mol file: 223910-48-3.mol

Synonyms:2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether

Chemical Property of 2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether

There total 5 articles about 2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trityl chloride (76-83-5) → 2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether (223910-48-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / Et₃N / acetonitrile / Ambient temperature

2: 1.) LiAlH₄, 2.) aq. NaOH / 1.) THF, 2.) THF, RT, 15 min

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF

With sodium hydroxide; lithium aluminium tetrahydride; sodium hydride; triethylamine; In acetonitrile;

DOI:10.1021/jm980408v

Reference yield:

(R)-histidine methyl ester dihydrochloride (4467-54-3,5619-10-3,7389-87-9,18684-16-7,22888-60-4,32381-17-2,92742-29-5,100009-20-9) → 2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether (223910-48-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / Et₃N / acetonitrile / Ambient temperature

2: 1.) LiAlH₄, 2.) aq. NaOH / 1.) THF, 2.) THF, RT, 15 min

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF

With sodium hydroxide; lithium aluminium tetrahydride; sodium hydride; triethylamine; In acetonitrile;

DOI:10.1021/jm980408v

Reference yield:

D-Histidine dihydrochloride → 2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether (223910-48-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / SOCl₂ / 60 °C

2: 100 percent / Et₃N / acetonitrile / Ambient temperature

3: 1.) LiAlH₄, 2.) aq. NaOH / 1.) THF, 2.) THF, RT, 15 min

4: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; sodium hydride; triethylamine; In acetonitrile;

DOI:10.1021/jm980408v

upstream raw materials:

1-bromomethyl-4-iodobenzene

2-(R)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanol ditrityl-D-histidinol

trityl chloride

(R)-histidine methyl ester dihydrochloride