3-ethyladamantan-1-amine

Base Information

• Chemical Name: 3-ethyladamantan-1-amine
• CAS No.: 41100-45-2
• Molecular Formula: C12H21N
• Molecular Weight: 179.305
• Hs Code.: 2921300090
• Mol file: 41100-45-2.mol

Synonyms:3-Ethyltricyclo[3.3.1.1^3,7]decan-1-amine;

Chemical Property of 3-ethyladamantan-1-amine

Chemical Property:

• Vapor Pressure: 0.0301mmHg at 25°C
• Refractive Index: 1.543
• Boiling Point: 244.6 °C at 760 mmHg
• PKA: 10.78±0.40(Predicted)
• Flash Point: 97.5 °C
• PSA: 26.02000
• Density: 1.029 g/cm³
• LogP: 3.39440
• Storage Temp.: Hygroscopic, Room Temperature, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(3-ethyl-1-adamantyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Ethyl 3,5-Didemethyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.

Technology Process of 3-ethyladamantan-1-amine

There total 7 articles about 3-ethyladamantan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-acetyl-3-ethyl-1-aminoadamantane (60931-65-9) → 1-amino-3-ethyl-adamantane (41100-45-2)

Guidance literature:

With sodium hydroxide; In diethylene glycol; Heating;

DOI:10.1021/jm00343a010

Reference yield:

2-(adamant-1-yl)ethanol (6240-11-5) → 1-amino-3-ethyl-adamantane (41100-45-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / pyridine / 1.) 0 deg C, 2 h, 2.) 6 deg C, overnight

2: 82 percent / LiEt₃BH / tetrahydrofuran / 15 h / Ambient temperature

3: 90.3 percent / Br₂ / 4 h / Heating

4: 91.6 percent / Heating

5: NaOH / bis-(2-hydroxy-ethyl) ether / Heating

With pyridine; sodium hydroxide; bromine; lithium triethylborohydride; In tetrahydrofuran; diethylene glycol;

DOI:10.1021/jm00343a010

Reference yield:

1-ethyladamantane (770-69-4) → 1-amino-3-ethyl-adamantane (41100-45-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 90.3 percent / Br₂ / 4 h / Heating

2: 91.6 percent / Heating

3: NaOH / bis-(2-hydroxy-ethyl) ether / Heating

With sodium hydroxide; bromine; In diethylene glycol;

DOI:10.1021/jm00343a010

upstream raw materials:

N-acetyl-3-ethyl-1-aminoadamantane

2-(adamant-1-yl)ethanol

1-ethyladamantane

1-Bromo-3-ethyladamantane

Downstream raw materials:

3-ethyl-1-aminoadamantane hydrochloride

Refernces

• 1、 -. "Novel treatment for alzheimer's disease". . . Retrieved 2009/11/30.
• 2、 -. "Pharmaceutical compositions comprising aminoadamantane derivatives". . . Retrieved 2010/01/07.