4-(2,2-dimethylbutyl)-2-{[4-(5-fluoropyridin-2-yl)phenyl]acetyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

Base Information

Chemical Name:4-(2,2-dimethylbutyl)-2-{[4-(5-fluoropyridin-2-yl)phenyl]acetyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide
CAS No.:1021733-22-1
Molecular Formula:C₂₃H₂₇FN₄O₃S
Molecular Weight:458.557
Hs Code.:

Synonyms:4-(2,2-dimethylbutyl)-2-{[4-(5-fluoropyridin-2-yl)phenyl]acetyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

Suppliers and Price of 4-(2,2-dimethylbutyl)-2-{[4-(5-fluoropyridin-2-yl)phenyl]acetyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-(2,2-dimethylbutyl)-2-{[4-(5-fluoropyridin-2-yl)phenyl]acetyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(2,2-dimethylbutyl)-2-{[4-(5-fluoropyridin-2-yl)phenyl]acetyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

There total 5 articles about 4-(2,2-dimethylbutyl)-2-{[4-(5-fluoropyridin-2-yl)phenyl]acetyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 41404-58-4
2-bromo-5-fluoropyridine

: 1021732-53-5
2-[(4-bromophenyl)acetyl]-4-(2,2-dimethylpropyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

: 1021733-22-1
4-(2,2-dimethylbutyl)-2-{[4-(5-fluoropyridin-2-yl)phenyl]acetyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hexamethyldistannane; In 1,4-dioxane; for 18h; Reflux;
DOI:10.1021/ml100196d

Reference yield:

: 1021732-05-7
4-(2,2-dimethylpropyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide

: 1021733-22-1
4-(2,2-dimethylbutyl)-2-{[4-(5-fluoropyridin-2-yl)phenyl]acetyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -10 °C

1.2: -10 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; hexamethyldistannane / 1,4-dioxane / 18 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; hexamethyldistannane; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/ml100196d

Reference yield:

: 2987-16-8
3,3-dimethylbutyrylaldehyde

: 1021733-22-1
4-(2,2-dimethylbutyl)-2-{[4-(5-fluoropyridin-2-yl)phenyl]acetyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C

1.2: 16 h / 100 °C / Sealed tube

2.1: dmap; triethylamine / dichloromethane / 18 h / Reflux

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -10 °C

3.2: -10 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; hexamethyldistannane / 1,4-dioxane / 18 h / Reflux

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium tert-butylate; hexamethyldistannane; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/ml100196d